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TBX5 Adult Knockout Left Atrial Gene Expression

ABSTRACT: TBX5 Adult Knockout Left Atrial Gene Expression

PROVIDER: PRJNA531601 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8868570.fastq.gz	Fastqsanger.gz
	SRR8868571.fastq.gz	Fastqsanger.gz
	SRR8868572.fastq.gz	Fastqsanger.gz
	SRR8868573.fastq.gz	Fastqsanger.gz
	SRR8868574.fastq.gz	Fastqsanger.gz

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TBX5 Adult Knockout Left Atrial Gene Expression

Project description:TBX5 removed from adult mice with R26CreERt2, left and right atrial RNA extracted and sequenced.

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Project description:TBX5 Adult Knockout Atrial ncRNA Expression [2023_eRNA]

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Transcriptional profiling of the peri-pulmonary vein region of the adult mouse left atrium and corresponding Tbx5-dependence

Project description:The left atrium consists of three major parts: the peri-pulmonary vein portion, the appendage, and the vestibule. Previous transcriptional profiling of the adult left atrium and identification of the Tbx5-dependent transcriptome has focused on the atrial appendage (Nadadur et al 2016, Science Translational Medicine). In that study, Tbx5 was shown to regulate a gene regulatory network of atrial identity in the appendage and in its absence results in atrial fibrillation. In order to investigate the regional differences in the transcriptome of the left atrium, the left atrial appendage and the peri-pulmonary vein portion from adult mice were compared by RNA-sequencing. Additionally, as Tbx5 is major regulator of atrial identity, the peri-pulmonary vein portion of the atria was likewise examined following removal of Tbx5 using an adult specific conditional knockout of Tbx5.

2020-03-10 | GSE128870 | GEO

TBX5 Adult Knockout Right Atrial Gene Expression [RA_RNAseq]

Project description:TBX5 Adult Knockout Right Atrial Gene Expression [RA_RNAseq]

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TBX5 Adult Knockout Right Atrial Gene Expression [RA_RNAseq]

Project description:TBX5 removed from adult mice with R26CreERt2, right atrial RNA extracted and sequenced.

2023-08-02 | GSE239809 | GEO

Tbx5 regulatory element controls atrial function and heart size II

Project description:Left atrial RNA-seq of Tbx5(REint), Tbx5(REdown), Tbx5(Reint);Prrx1(RE) and control adult mice

2023-02-10 | GSE189342 | GEO

TBX5 Adult Knockout Atrial ncRNA Expression [2023_eRNA]

Project description:We deep sequenced wildtype and Tbx5-mutant mouse atria, identifying ~2600 novel Tbx5-dependent ncRNAs. Tbx5-dependent ncRNA transcription provided a quantitative metric of Tbx5-dependent enhancer activity, correlating with target gene expression.

2023-08-02 | GSE239805 | GEO

Gene expression in rabbit left atrial free wall and left atrial appendage

Project description:RNA sequencing of dissected left atrial free wall and left atrial appendage of adult New Zealand White rabbit

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Reduced TBX5 dosage causes human atrial disease by undermining developmental gene regulation of atrial cardiomyocyte identity [scRNA-seq]

Project description:In a TBX5-linked human cellular model of atrial disease, we examined the gene networks controlled by TBX5 during human atrial differentiation using single-cell RNA and ATAC sequencing.

2025-02-18 | GSE285169 | GEO

CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes

Project description:Atrial fibrillation (AF), the most common sustained arrhythmia, affects 59 million individuals worldwide. The transcription factor TBX5 is essential for normal atrial rhythm, and its inactivation causes loss of aCM enhancer accessibility, looping, and transcriptional identity, and causes spontaneous AF. Here we investigated mechanisms by which TBX5 regulates chromatin organization. We found that TBX5 recruits CHD4, a chromatin remodeling ATPase canonically associated with the NuRD repressor complex, to 33,170 genomic regions (TBX5-enhanced CHD4 sites). Combined snRNA-seq and snATAC-seq of CHD4 knockout (KO) and control aCMs revealed that CHD4 has both gene activator and repressor functions. CHD4-repressed genes included sarcomeric proteins from non-CM cell lineages. CHD4-activated genes were characterized by TBX5-enhanced CHD4 recruitment, which enhanced chromatin accessibility and promoted the expression of aCM identity genes. This mechanism of TBX5 recruitment of CHD4 was critical for sinus rhythm because Chd4AKO mice had increased vulnerability to AF. Our findings reveal that CHD4 is essential for maintaining aCM gene expression, aCM identity, and atrial rhythm homeostasis.

2025-08-04 | GSE296675 | GEO

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