Project description:Hyaluronidases was reported to be effective in lung fibrosis therapy, and HYAL1 was found to inhibit TGF-β1 mediated cell growth in murine L929 fibroblasts, while the underlying mechanism of HYAL1 in regulating human lung fibroblasts is largely unknown. We used microarray to detail the gene expression of HYAL1 overexpression HFL-1 fibroblasts, and found significantly downregulated genes.
Project description:We profiled the global gene expression of human primary fetal lung fibroblasts (HFL-1) at different stages while they were undergoing replicative senescence