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Transcriptional analysis of tendons from mice with a tenocyte-specific deletion of IGF1R

ABSTRACT: Transcriptional analysis of tendons from mice with a tenocyte-specific deletion of IGF1R

PROVIDER: PRJNA544963 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9130300.fastq.gz	Fastqsanger.gz
	SRR9130310.fastq.gz	Fastqsanger.gz
	SRR9130320.fastq.gz	Fastqsanger.gz
	SRR9130330.fastq.gz	Fastqsanger.gz
	SRR9130340.fastq.gz	Fastqsanger.gz

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Transcriptional analysis of tendons from mice with a tenocyte-specific deletion of IGF1R

Project description:We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the IGF1 receptor (IGF1R) present in their tendons (Scx:IGF1R+) or mice in which IGF1R has been deleted in tenocytes expressing scleraxis (Scx:IGF1R-). Mice were created by crossing ScxCreERT2 mice with IGF1R flox/flox mice. Mice were treated with tamoxifen for 5 days to induce recombination at the IGF1R allele, and then subjected to a synergist ablation procedure in which the Achilles tendon is removed, resulting in compensatory growth of the plantaris tendon. Mice were analyzed either 7 or 14 days after synergist ablation. Control mice that did not undergo tamoxifen treatment or synergist ablation were also studied.

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Project description:We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus (Scx-). Mice in which scleraxis was deleted were created by crossing scleraxis-floxed mice with Rosa26-CreERT2 mice. Rosa26-CreERT2 mice that did not have a floxed scleraxis allele served as controls. Mice were treated with tamoxifen for 5 days to induce recombination at the scleraxis locus, and then subjected to a synergist ablation procedure in which the Achilles tendon is removed, resulting in compensatory growth of the plantaris tendon. Mice were analyzed either 7 or 14 days after synergist ablation. Control mice that did not undergo tamoxifen treatment or synergist ablation were also studied (NOC).

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Transcriptional analysis of tendons from rat

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