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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

ABSTRACT: Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

PROVIDER: PRJNA549886 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9331772.fastq.gz	Fastqsanger.gz
	SRR9331773.fastq.gz	Fastqsanger.gz
	SRR9331774.fastq.gz	Fastqsanger.gz
	SRR9331775.fastq.gz	Fastqsanger.gz
	SRR9331776.fastq.gz	Fastqsanger.gz

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:Purpose: Analysis of downstream pathways activated by NPMc+ and Flt3-ITD oncogenes in preleukemic hematopoietic stem cells (HSCs). Methods: RNA extracted and processed from MxCRE, Flt3-ITD and NPMc+/Flt3-ITD FACS sorted HSCs Results: These data demonstrate that NPMc+ expression in Flt3-ITD HSCs promote a transcriptional program that supports both self-renewal and quiescence.

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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