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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

ABSTRACT: Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

PROVIDER: PRJNA549913 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9331780_1.fastq.gz	Fastqsanger.gz
	SRR9331780_2.fastq.gz	Fastqsanger.gz
	SRR9331781_1.fastq.gz	Fastqsanger.gz
	SRR9331781_2.fastq.gz	Fastqsanger.gz
	SRR9331772.fastq.gz	Fastqsanger.gz

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:Purpose: Analysis of downstream pathways activated by NPMc+ and Flt3-ITD oncogenes in preleukemic hematopoietic stem cells (HSCs). Methods: RNA extracted and processed from MxCRE, Flt3-ITD and NPMc+/Flt3-ITD FACS sorted HSCs Results: These data demonstrate that NPMc+ expression in Flt3-ITD HSCs promote a transcriptional program that supports both self-renewal and quiescence.

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Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:The most frequent mutation in AML patients with normal karyotype affects the Nucleophosmin gene (NPMc+). Different mouse models have shown that NPMc+ mutation can drive leukemia development. In this study, the impact of NPMc+ expression on the transcriptional program of mouse hematopietic stem cells (HSC) in vivo has been investigated.

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Project description:Analysis of the transcriptional profile imposed by NPMc+ and Flt3-ITD oncogenes, both alone and in cooperation, on HSCs at single cell level

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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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