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ABSTRACT: Microbiome changes after tocotrienol supplementation in high-fat diet-induced obese mice

PROVIDER: PRJNA551310 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11942957_1.fastq.gz	Fastqsanger.gz
	SRR11942957_2.fastq.gz	Fastqsanger.gz
	SRR11942958_1.fastq.gz	Fastqsanger.gz
	SRR11942958_2.fastq.gz	Fastqsanger.gz
	SRR11942959_1.fastq.gz	Fastqsanger.gz

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Project description:Microbiome changes after green tea polyphenols and tocotrienols supplementation in high-fat diet-induced obese mice

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Folic acid supplementation alters the DNA methylation profile and improves insulin resistance in high-fat-diet-fed mice

Project description:Folic acid (FA) supplementation may protect from obesity and insulin resistance, the effects and mechanism of FA on chronic high-fat-diet-induced obesity-related metabolic disorders are not well elucidated. We adopted a genome-wide approach to directly examine whether FA supplementation affects the DNA methylation profile of mouse adipose tissue and identify the functional consequences of these changes. Mice were fed a high-fat diet (HFD), normal diet (ND) or an HFD supplemented with folic acid (20 μg/ml in drinking water) for 10 weeks, epididymal fat was harvested, and genome-wide DNA methylation analyses were performed using methylated DNA immunoprecipitation sequencing (MeDIP-seq). Mice exposed to the HFD expanded their adipose mass, which was accompanied by a significant increase in circulating glucose and insulin levels. FA supplementation reduced the fat mass and serum glucose levels and improved insulin resistance in HFD-fed mice. MeDIP-seq revealed distribution of differentially methylated regions (DMRs) throughout the adipocyte genome, with more hypermethylated regions in HFD mice. Methylome profiling identified DMRs associated with 3787 annotated genes from HFD mice in response to FA supplementation. Pathway analyses showed novel DNA methylation changes in adipose genes associated with insulin secretion, pancreatic secretion and type 2 diabetes. The differential DNA methylation corresponded to changes in the adipose tissue gene expression of Adcy3 and Rapgef4 in mice exposed to a diet containing FA. FA supplementation improved insulin resistance, decreased the fat mass, and induced DNA methylation and gene expression changes in genes associated with obesity and insulin secretion in obese mice fed a HFD.

2018-06-30 | GSE97576 | GEO

Gene expression profiles of the prostates of prostate-specific Pten-/- mice

Project description:We reported the gene expression profiles of prostate dorsal-lateral-ventral glands of prostate-specific Pten-/- mice on AIN93M diet, 60%Kcal high-fat diet, and AIN93M diet containing 0.05% delta-tocotrienol at 20 weeks of age.

2021-09-10 | GSE182980 | GEO

Proteomic analysis of brown adipose tissue from obesity mice induced by high-fat diet

Project description:This project includes proteomic data of brown adipose tissue from high-fat diet-induced obese mice versus wild-type mice. WTB reprents the brown adipose tissue from wild-type mice.DIOB reprents the brown adipose tissue from diet-induced obesity mice.

2026-05-22 | PXD067866 | Pride

Dietary curcumin ameliorates perturbed insulin homeostasis in the diet-induced obese aged mice

Project description:Although aging is a physiological process to which all organisms are subject, the presence of obesity and type 2 diabetes accelerates biological aging. Recent studies have demonstrated the causal relationships between dietary interventions suppressing obesity and type 2 diabetes and delaying the onset of age-related endocrine changes. Curcumin, a natural antioxidant, has putative therapeutic properties such as reinstating insulin sensitivity in obese mice. However, how curcumin contributes to maintaining insulin homeostasis in aged organisms largely remains unclear. Thus, the objective of this study is to examine the pleiotropic effect of dietary curcumin on insulin homeostasis in a diet-induced obese (DIO) aged mouse model. Aged (18-20 months old) male mice given a high-fat high-sugar diet supplemented with curcumin displayed a different metabolic phenotype compared to mice given a high-fat high-sugar diet alone. Furthermore, curcumin supplementation altered hepatic gene expression profiling, especially insulin signaling and senescence pathways. We then mechanistically investigated how curcumin functions to fine-tune insulin sensitivity. We found that curcumin supplementation increased hepatic insulin degrading enzyme (IDE) expression levels and preserved islet integrity, both of which are beneficial during aging. Our findings suggest that the multifaceted therapeutic potential of curcumin can be used as a protective agent for age-induced metabolic diseases.

2021-11-04 | GSE186971 | GEO

Proteomic analysis of inguinal white adipose tissue from obesity mice induced by high-fat diet

Project description:This project includes proteomic data of inguinal white adipose tissue from high-fat diet-induced obese mice versus wild-type mice. WTi reprents the inguinal white adipose tissue from wild-type mice.DIOi reprents the inguinal white adipose tissue from diet-induced obesity mice.

2026-05-22 | PXD067877 | Pride

Hepatocyte-specific knockout of Nicotinamide phosphoribosyltransferase increases susceptibility for liver fibrosis in mice

Project description:We investigated the plasma and liver proteome changes in liver fibrosis in mice induced by hepatocyte-specific knockout of nicotinamide phosphoribosyltransferase (Nampt) upon a low-methionine, choline-free 60% high-fat (MCD) diet at multiple time points. We also investigated whether supplementation with nicotinamide riboside could alleviate liver injury and how the liver proteome changes upon NR supplementation.

2021-11-04 | PXD017170 | Pride

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