Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rat (Wistar) Liver CDAA Diet 4-8-12 Weeks Ensembl84 (BIBC)

ABSTRACT: Rat (Wistar) Liver CDAA Diet 4-8-12 Weeks Ensembl84 (BIBC)

PROVIDER: PRJNA556214 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9734300.fastq.gz	Fastqsanger.gz
	SRR9734310.fastq.gz	Fastqsanger.gz
	SRR9734320.fastq.gz	Fastqsanger.gz
	SRR9734330.fastq.gz	Fastqsanger.gz
	SRR9734340.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Rat (Wistar) Liver CDAA Diet 4-8-12 Weeks Ensembl84 (BIBC)

Project description:Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be useful for drug development. Here we present a multi-omics approach to characterize the molecular pathophysiology and to identify new plasma biomarkers in a choline-deficient L-amino acid-defined diet rat NASH model. We analyzed liver samples by RNA-Seq and proteomics, revealing disease relevant signatures and a high correlation between mRNA and protein changes. Comparison to human data showed an overlap of inflammatory, metabolic, and developmental pathways.

2020-01-27 | GSE134715 | GEO

Expression data of primary murine liver sinusoidal endothelial cells after 10 weeks of CDAA diet

Project description:Liver sinusoidal endothelial cells (LSEC) constitute discontinuous, permeable microvessels, with a characteristic program of gene expression that differs significantly from continuous microvascular endothelial cells e.g. in the lung. LSEC play a pivotal role in liver fibrogenesis in the CDAA dietary model of non-alcoholic steatohepatitis (NASH). We used microarrays to analyse the program of gene expression in murine liver endothelial cells after 10 weeks of CDAA diet.

2020-09-15 | GSE140994 | GEO

Transcriptomic analysis of primary hepatocytes and total livers from WT mice fed with CSAA or CDAA-HSHC diet during 2 weeks.

Project description:Mouse primary hepatocytes (PH) and total livers (TL) prepared from C57Bl6 male adult mice which were fed either a CDAA supplemented cholesterol with glucose and fructose or a CSAA diet during 2 weeks.

2024-04-01 | GSE212617 | GEO

Wistar rat, lung, NanoLC-MS/MS

Project description:Wistar rats, male, treated with 500 mg/Kg/day of diacetyl by gavage, during 4 weeks

2018-04-18 | PXD004504 | Pride

The CdaA Regulon in Streptoccus mutans

Project description:Nucleotide signaling pathways are found in all kingdoms of life and are utilized to coordinate a rapid response to changes in the environment. One more recently discovered signaling nucleotide is the secondary messenger cyclic diadenosine monophosphate (c-di-AMP), which is widely distributed among bacteria and is also found in several archaea. This cyclic nucleotide has been shown to involve in several important cellular processes, including maintenance of DNA integrity, cell wall metabolism, stress tolerance, transcription regulation and virulence. However, the mechanisms by which c-di-AMP modulates these physiological changes have remained largely unknown.In the present study, we identified and characterized a c-di-AMP synthase (CdaA) in S. mutans UA159. Furthermore, we investigated the role of CdaA in S. mutans cell physiology and global gene expression by utilizing cdaA gene in-frame deletion mutant. Our findings suggest that CdaA is an important global modulator of optimal growth and environmental adaption in this pathogen. Streptococcus mutans UA159 whole-genome arrays (8 x 15 K) were obtained from Agilent and included 1998 probes for S. mutans transcripts. For microarray analysis, S. mutans UA159 and S. mutans ?cdaA cells were routinely grown at 37°C anaerobically (90% N2, 5% CO2, 5% H2) in brain heart infusion broth (BHI; Difco, Sparks, MD, USA) to an optical density at 600 nm (OD600) of 0.5. Four RNA samples isolated from four independent cultures of UA159 and cdaA mutant strains were hybridized to the arrays and analyzed.

2015-04-06 | E-GEOD-65511 | biostudies-arrayexpress

Expression data of primary murine liver sinusoidal endothelial cells after 10 weeks of CDAA diet

Project description:Expression data of primary murine liver sinusoidal endothelial cells after 10 weeks of CDAA diet

| PRJNA591629 | ENA

Wistar rat

Project description:Wistar rat Raw sequence reads-Sr

| PRJNA986280 | ENA

Hepatoprotective effects of late-stage clinical drug candidates and dietary intervention in the non-obese CDAA-HFD mouse model of advanced MASH with progressive fibrosis

Project description:We applied RNA sequencing (RNA-seq) to study the gene expression profile in the liver of mice fed the CDAA-HFD for 3 weeks (n=9), 6 weeks (n=10), 12 weeks (n=8) and 20 weeks (n=8) and lean chow controls (n=8). At all timepoints, CDAA-HFD mice displayed a widespread increase in the expression of MASH candidate genes related to inflammation, hepatocellular injury and ECM organization as compared to chow-fed controls. Gene expression was further studied in response to chow reversal (n=9), semaglutide (n=9) and lanifibranor (n=10) as compared to Vehicle (n=10). Chow reversal and lanifibranor, induced wide-spread transcriptional changes in MASH candidate genes while semaglutide showed only discrete effects on candidate genes.

2024-10-10 | GSE269493 | GEO

The CdaA Regulon in Streptoccus mutans

2015-04-06 | GSE65511 | GEO

SAGE profile of rat hippocampus mRNA from Wistar rats

Project description:SAGE profile of rat hippocampus mRNA from Wistar rats

2010-12-01 | GSE25750 | GEO