The CdaA Regulon in Streptoccus mutans

ABSTRACT: Nucleotide signaling pathways are found in all kingdoms of life and are utilized to coordinate a rapid response to changes in the environment. One more recently discovered signaling nucleotide is the secondary messenger cyclic diadenosine monophosphate (c-di-AMP), which is widely distributed among bacteria and is also found in several archaea. This cyclic nucleotide has been shown to involve in several important cellular processes, including maintenance of DNA integrity, cell wall metabolism, stress tolerance, transcription regulation and virulence. However, the mechanisms by which c-di-AMP modulates these physiological changes have remained largely unknown.In the present study, we identified and characterized a c-di-AMP synthase (CdaA) in S. mutans UA159. Furthermore, we investigated the

ORGANISM(S): Streptococcus mutans

SUBMITTER: Yu-Qing Li 

PROVIDER: E-GEOD-65511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress