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Transcriptomic analysis of dj-1-/- zebrafish brains compared to wild type siblings

ABSTRACT: Transcriptomic analysis of dj-1-/- zebrafish brains compared to wild type siblings

PROVIDER: PRJNA558074 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9886610_1.fastq.gz	Fastqsanger.gz
	SRR9886610_2.fastq.gz	Fastqsanger.gz
	SRR9886611_1.fastq.gz	Fastqsanger.gz
	SRR9886611_2.fastq.gz	Fastqsanger.gz
	SRR9886606_1.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of dj-1-/- zebrafish brains compared to wild type siblings

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Project description:Mutations in the DJ-1 (Park7) gene cause autosomal recessive Parkinson's disease in humans, but the function of the DJ-1 protein is poorly characterized. In an effort to understand more about the biology of DJ-1, we performed iTRAQ analyses on subcellular fractions enriched from DJ-1 knockout rat and mouse brains. We generated iTRAQ datasets for mitochondria and cytosol enriched fractions from 6-month-old rat brains, and the cytosol enriched fraction from 14-15-month old mouse brains. Our subsequent analyses of these datasets led to our discovery that the Hexokinase 1 protein was increased in the cytosol components of both DJ-1 knockout species.

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