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Ketogenic diet activates protective γδ T cell responses against influenza virus infection

ABSTRACT: Ketogenic diet activates protective γδ T cell responses against influenza virus infection

PROVIDER: PRJNA562635 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10034233.fastq.gz	Fastqsanger.gz
	SRR10034234.fastq.gz	Fastqsanger.gz
	SRR10034235.fastq.gz	Fastqsanger.gz
	SRR10034236.fastq.gz	Fastqsanger.gz
	SRR10034237.fastq.gz	Fastqsanger.gz

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Ketogenic diet activates protective γδ T cell responses against influenza virus infection

Project description:Influenza A virus (IAV) infection-associated morbidity and mortality are a key global healthcare concern, necessitating the identification of novel therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ T cells in the lung that improved barrier functions, thereby enhancing anti-viral resistance. Expansion of these protective γδ T cells required metabolic adaptation to a ketogenic diet, as neither feeding mice a high-fat high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD mediated immune-metabolic integration represents a viable avenue towards preventing or alleviating influenza disease.

2019-08-29 | GSE136536 | GEO

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]

Project description:Ketone bodies are essential alternative fuels that allow humans to survive periods of glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet (KD), that is extremely high in fat with very-low carbohydrates, drives the host into using β-hydroxybutyrate (BHB) for the production of ATP and lowers NLRP3-mediated inflammation. However, the extremely high fat composition of KD raises the question of how ketogenesis impacts adipose tissue to control inflammation and energy homeostasis. Using single-cell RNA sequencing of adipose tissue-resident immune cells, we identified that KD expands metabolically protective γδ T cells that restrain inflammation. However, a long-term KD caused obesity, impaired metabolic health and depleted the adipose resident γδ T cells. Moreover, mice lacking γδ T cells have impaired glucose homeostasis. We conclude that γδ T cells are mediators of protective immunometabolic responses that link fatty acid driven fuel utilization to reduced adipose tissue inflammation.

2019-09-10 | GSE137076 | GEO

Ketogenic diet activates protective γδ T cell responses against influenza virus infection.

Project description:Influenza A virus (IAV) infection-associated morbidity and mortality are a key global health care concern, necessitating the identification of new therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ T cells in the lung that improved barrier functions, thereby enhancing antiviral resistance. Expansion of these protective γδ T cells required metabolic adaptation to a ketogenic diet because neither feeding mice a high-fat, high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD-mediated immune-metabolic integration represents a viable avenue toward preventing or alleviating influenza disease.

| S-EPMC7189564 | biostudies-literature

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [bulk RNA-Seq]

2019-09-10 | GSE137073 | GEO

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

Project description:Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

| PRJNA564510 | ENA

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]

Project description:Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]

| PRJNA564513 | ENA

γδ T cells orchestrate the induction of protective type 2 immunity in neonatal influenza infection

Project description:Influenza infection causes high rates of hospitalization and mortality in infants. γδ T cells are critical for immune responses against pathogens as regulators and effectors, especially in infants, and yet the roles of neonatal γδ T cells in influenza remain to be investigated. Here we report that γδ T cells were protective against mortality associated with neonatal influenza infection. Infection induced the accumulation and activation of γδ T cells, which transiently expressed IL-17a to enhance early IL-33 production by lung epithelial cells via STAT3 phosphorylation. Subsequently, this led to type 2 immune responses with elicited infiltration of ILC2s and Tregs resulting in increased amphiregulin secretion and tissue repair. Loss of γδ T cells did not alter viral clearance or IFN-γ production. Thus, our results identify a specific requirement for γδ T cells in influenza-infected neonates by initiating type 2 immune responses, mediating tissue homeostasis, and promoting lung integrity.

2018-06-20 | GSE99683 | GEO

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [bulk RNA-Seq]

Project description:Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [bulk RNA-Seq]

| PRJNA564506 | ENA

Kainic acid-administered Rat brain: control vs Ketogenic diet-fed

Project description:The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model were analyzed. Two-condition experiment, Normal diet-fed rat brain vs. Ketogenic diet-fed rat brain. Duplicate per array

2010-05-19 | E-GEOD-19277 | biostudies-arrayexpress

Myocardial expression data from ketogenic diet-fed mice

Project description:Specific pathogen free wild-type C57Bl/6 male mice fed ketogenic diet (Bio-Serv AIN-76-A) for 4 weeks Keywords: RNA Expression Array Hearts from 12 week-old mice that were maintained on a standard polysacchardide-rich chow until the age of 8 weeks, at which time they were switched to a ketogenic diet (ad libitum) and maintained for 4 additional weeks prior to collection of tissues

2010-06-16 | E-GEOD-21368 | biostudies-arrayexpress

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