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Identification of miRNAs as biomarkers of drug response of Pien Tze Huang in Hepatic Fibrosis Treatments

ABSTRACT: Identification of miRNAs as biomarkers of drug response of Pien Tze Huang in Hepatic Fibrosis Treatments

PROVIDER: PRJNA564553 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10085817.fastq.gz	Fastqsanger.gz
	SRR10085818.fastq.gz	Fastqsanger.gz
	SRR10085819.fastq.gz	Fastqsanger.gz
	SRR10085820.fastq.gz	Fastqsanger.gz
	SRR10085821.fastq.gz	Fastqsanger.gz

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Identification of miRNAs as biomarkers of drug response of Pien Tze Huang in Hepatic Fibrosis Treatments

Project description:Pien Tze Huang (PZH) is herbal traditional Chinese medicine which was widely utilized in Asia for hepatic diseases. We constructed two groups hepatic fibrosis mice model using CCl4, one group using PZH treatment and another group replacing PZH with double distilled water. All 12 mice were fed for 8 weeks and then killed to have their liver tissue taken out. Small RNA-seq were used to identify miRNAs of PZH medicine effect for hepatic fibrosis. We found the expression of these miRNAs (mmu-miR-205-5p, mmu-miR-3064-5p, mmu-miR-205-5p, mmu-miR-370-3p, mmu-miR-665-3p) were changed in PZH medicine treatment for hepatic fibrosis study. Furthermore, Hmga2 and Fgf9, miRNAs corresponding target genes (Sp4, Slc2a6, Tln2, Hmga2, Ank3, Pax9, Fgf9), have been reported association with hepatic fibrosis.

2021-06-28 | GSE137100 | GEO

Pien-Tze-Huang Promotes Hepatocellular Carcinoma Cell Ferroptosis by Inhibiting SLC7A11-GSH-GPX4 Axis

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Pien Tze Huang, a traditional Chinese medicine, in maintenance treatment of metastatic colorectal cancer: a prospective, multiple center, randomized, double-blind, placebo-controlled study

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Protective effect of Pien Tze Huang on colitis-associated colorectal cancer

Project description:The goal of this study is to compare the differentially expressed genes in colon tissue of Control and AOM/DSS induced colitis-associated cancer (CAC) mouse model with or without Pien Tze Huang (PZH) treatment. The AOM/DSS induced CAC mouse model were randomly divided into 2 groups: Model and Model + PZH groups (n=5 for each group). Control mice (n=5) were set as control. mice in Control and Model groups were intragastrically with double distilled water, while mice in PZH and Model + PZH groups were intragastrically with 250 mg/kg/d of PZH for 91 days. Then the colon tissues were used to identify differentially expressed genes among different groups.

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Transcriptome Analysis Reveals Potential Protective Effects and Biomarkers of Pien Tze Huang on CCl4-induced Liver Cancer (circRNA)

Project description:Pien Tze Huang (PZH) is a traditional Chinese medicine which was widely utilized in Asia for hepatic diseases. We construct two groups liver cancer mice model using CCl4, one group using PZH treatment and another group didn?t treatment. We found that the liver functional indices including ALB, ALT and AST were significantly increased in non-PZH treatment group. HE staining showed that inflammation was emerged surrounding the hepatic vein in the non-PZH treatment group, Masson staining revealed that there are blue collagenous fibre surrounding hepatic vein in the non-PZH treatment group, this result indicated that PZH cured the hepatic inflammation and cancer. We performed the mRNA,LncRNA,ciecRNA and miRNA sequencing aim to explore the drug target using PZH treatment on transcriptome level. 478 protein coding transcripts and 68 lncRNA transcripts were differentially expressed. Our research provided potential transcriptional therapeutic target for the clinical treatment using PZH.

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Transcriptomic analysis reveals the protective biomarkers of Pien Tze Huang in liver cirrhosis mice model [miRNA]

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Project description:This study aimed to investigate the global effect of Chinese medicine formula Pien Tze Huang on hepatocellular carcinoma (HCC) compared with the anti-tumor agent sorafenib based on tandem mass tag label proteomic and phosphoproteomic analysis in addition to parallel reaction monitoring verification.

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Target identification of hepatic fibrosis therapy using Pien Tze Huang based on mRNA and lncRNA

Project description:Pien Tze Huang (PZH) is a traditional Chinese medicine which was widely utilized in Asia for hepatic diseases. We construct two groups hepatic fibrosis mice model using CCl4, one group using PZH treatment and another group didn’t treatment. We found that the liver functional indices including ALB, ALT and AST were significantly increased in non-PZH treatment group. HE staining showed that inflammation was emerged surrounding the hepatic vein in the non-PZH treatment group, Masson staining revealed that there are blue collagenous fibre surrounding hepatic vein in the non-PZH treatment group, this result indicated that PZH cured the hepatic inflammation and fibrosis. We performed the mRNA and LncRNA sequencing aim to explore the drug target using PZH treatment on transcriptome level. 905 protein coding transcripts and 23 lncRNA transcripts were differentially expressed. Our research provided potential transcriptional therapeutic target for the clinical treatment using PZH.

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