Project description:Here we report metagenomic sequencing data in gut microbiota of autism spectrum disorders (ASD) compared with healthy volunteers (30 for ASD children and 30 for healthy controls, respectively). The genes changed in autistic subjects involved 1,312,364 analytes that compare to 1,335,835 analytes in healthy controls. The number of taxa in autistic subjects were significantly increased as compared to the healthy controls based on the phylum and genus level (P = 0.001). However, the number of species were significantly decreased in autistic subjects (P = 0.001).
Project description:<p>Traditional Chinese Medicine Dachaihu decoction (DCHD) has been reported to hold great promise to alleviate autism spectrum disorders (ASD), a generalized neurodevelopmental disease associated with gut microbiome dysbiosis. Health-promoting effects of DCHD on ASD children could be attributed to gut microbiota reconstruction. However, its underlying mechanism of action remains elusive, resulting in rare therapies have proposed for TCM-targeted modulation of gut microbiota for the treatment of ASD. This study aimed to investigate the mechanisms by which DCHD alleviates ASD severity and social disorder, with particular emphasis on gut microbiota composition and metabolism.</p>
2025-12-12 | MTBLS13501 | MetaboLights
Project description:Gut microbiota profile in Autism Spectrum Disorders patients
| PRJNA754695 | ENA
Project description:Gut microbiota of children with Autism Spectrum Disorder
Project description:Changes in gut microbiota have been implicated in pathophysiology and cognitive capabilities of patients suffering from autism spectrum disorder. Yet, factors that mediate this interaction remain not fully understood. In this study, we analyzed stool samples from sever autistic pediatric patients and healthy individuals. Using multi omics platforms, we characterized microbiota diversities, proteins, and possible altered metabolic pathways.
Project description:Here we report 16S rRNA data in gut microbiota of autism spectrum disorders compared with healthy volunteers. A total of 1322 operational taxonomic units (OTUs) were identified in the sequence data. The Bacteroidetes and Firmicutes were both dominated phylum in ausitic subjects and healthy controls. Phylum level analysis showed a clear alteration of the bacterial gut community in ASD characterized by a higher Firmicutes (P < 0.05), Proteobacteria (P < 0.001), and Actinobacteria (P < 0.001) than that in healthy controls. However, Bacteroidetes were significantly decreased in ASD patients (P < 0.001).
