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Dynamic changes in gene expression profile during differentiation of iPS into MSCs

ABSTRACT: Dynamic changes in gene expression profile during differentiation of iPS into MSCs

PROVIDER: PRJNA589829 | ENA |

REPOSITORIES: ENA

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Dynamic changes in gene expression profile during differentiation of iPS into MSCs

Project description:Analysis of gene expression profile at different developmental stages of MSCs. iPS cells from human fibroblasts are differentiated into MSCs undergoing primitive streak and mesoderm. Results provide important information of dynamic changes in gene expression profile during MSC development.

2019-11-16 | GSE140450 | GEO

WT MSCs displayed a different transcriptional profile than KO MSCs.

Project description:WT MSCs displayed a different transcriptional profile than KO MSCs.

| PRJNA896921 | ENA

Gene expression profile of modified MSCs

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Purified mesenchymal stem cells are an efficient source for iPS cell induction

Project description:The ectopic expression of a defined set of transcription factors, Oct4, Klf4, Sox2, and c-Myc, reprograms mouse embryonic fibroblasts (MEFs) and adult tail-tip fibroblasts (TTFs) into embryonic stem (ES)-like cells called induced pluripotent stem (iPS) cells. iPS cells have been generated from a variety of somatic cells, including embryonic and adult dermal fibroblasts, epithelial cells of the liver and stomach, pancreatic b cells, mature B lymphocytes, and adult neural stem cells (NSCs). While these studies demonstrated that most somatic cells are capable of acquiring pluripotency with minimal gene transduction, the poor efficiency of cell reprogramming and the uneven quality of iPS cells are still important problems. In particular, the choice of cell type most suitable for inducing high-quality iPS cells remains unclear. Here, we generated iPS cells from PDGFRa+ Sca-1+ (PaS) cells that represent highly enriched adult mouse mesenchymal stem cells (MSCs) and PDGFRa- Sca-1- osteo-progenitor (OP) cells. When we compared the induction efficiency and quality of individual iPS clones, MSCs had a higher reprogramming efficiency compared with OP cells and TTFs. The iPS cells induced from MSCs by Oct3/4, Sox2, and Klf4 appeared to be the closest equivalent to ES cells by DNA microarray gene profile and germline-transmission efficiency. We conclude that prospectively isolated MSCs are a promising candidate for the efficient and stable generation of high-quality iPS cells.

2010-08-21 | GSE23717 | GEO

Comparison of mesenchymal stem/stromal cells (MSCs) between human iPS-derived MSC and human primary cultured MSCs

Project description:Comparison of mesenchymal stem/stromal cells (MSCs) between human iPS-derived MSC and human primary cultured MSCs

| PRJNA849564 | ENA

methylation profile of dermal MSCs derived from psoriasis patients and normal control

Project description:Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear.We have found that the gene expression profile of psoriatic dermal MSCs was distinct different from normal MSCs. We proposed to investigate the DNA methylation profile of psoriatic MSCs. 6 patients and 6 normal control were inrolled in the study, the DNA methylation profile of dermal MSCs were studied using the microarry.

2012-11-30 | E-GEOD-42634 | biostudies-arrayexpress

Comparison of the migration profile of MSCs

Project description:To compare the gene expression profile of MSCs harvested from bone marrow in the context of cell migration.

2009-07-14 | GSE12098 | GEO

methylation profile of dermal MSCs derived from psoriasis patients and normal control

2012-11-30 | GSE42634 | GEO

Transcription profile of SSEA-3-positive population of MSCs

Project description:Microarray analysis of the gene expression profile of SSEA-3-positive human adipose-derived MSCs were performed.

2015-01-07 | GSE55526 | GEO

microRNA expression profile of dermal MSCs derived from psoriasis patients and normal control

Project description:Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear. We proposed to investigate the microRNA expression profile of psoriatic MSCs. 6 patients and 6 normal control were inrolled in the study, the microRNA expression profile of dermal MSCs were studied using the microarry.

2012-11-30 | E-GEOD-42633 | biostudies-arrayexpress

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