Project description:We employed a proteogenomics workflow to identify microproteins encoded by small Open Reading Frames (ORFs) in the genome of Mycobacterium smegmatis strain mc²155.

2022-04-21 | PXD025604 | JPOST Repository

Comparative transcriptomics of Mycobacterium bovis and Mycobacterium marinum

Project description:Related surrogate species are often used to study the molecular basis of pathogenicity of a pathogen on the basis of a shared set of biological features generally attributable to a shared core genome consisting of orthologous genes. An important and understudied aspect, however, is the extent to which regulatory features affecting the expression of such shared genes are present in both species. Here we report on an analysis of whole transcriptome maps for an important member of the TB complex Mycobacterium bovis and a closely related model organism for studying mycobacterial pathogenicity Mycobacterium marinum.

2014-09-08 | GSE51881 | GEO

Transcriptome profiling of two novel Mycobacterium species, Mycobacterium camsae and Mycobacterium pumcae

Project description:This study performed transcriptome sequencing of two newly identified Mycobacterium species, Mycobacterium camsae and Mycobacterium pumcae, under standard culture conditions to establish baseline gene expression profiles. RNA was extracted from cells grown to mid-log phase in standard medium and sequenced using Illumina paired-end technology. The data provide a foundational resource for future functional studies of these novel strains.

2026-05-15 | GSE328954 | GEO

Comparative transcriptomics of Mycobacterium bovis and Mycobacterium marinum

2014-09-08 | E-GEOD-51881 | biostudies-arrayexpress

Genome-wide maps of gene transcription levels in RAW264.7 infected with CdhM-related Mycobacterium tuberculosis H37Ra strain.

Project description:We report the application of RNA-seq technology for high-throughput profiling of gene transcription in RAW264.7 infected with Mycobacterium tuberculosis H37Ra. By obtaining over six billion bases of sequence from mRNA, we generated genome-wide gene transcription maps of RAW264.7 infected with CdhM-related Mycobacterium tuberculosis H37Ra. We find that numerous genes involved in ER stress are significantly affected by CdhM. This finding indicates that CdhM may induce ER stress during Mtb infection of host cells.

2022-02-24 | GSE196961 | GEO