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Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [hADSCs]

ABSTRACT: Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [hADSCs]

PROVIDER: PRJNA590665 | ENA |

REPOSITORIES: ENA

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Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [hADSCs]

Project description:We implemented transcriptomic analyses of hADSCs treated with metformin 6 days

2020-09-23 | GSE140714 | GEO

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis

Project description:Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis

| PRJNA590654 | ENA

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [blood]

Project description:Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [blood]

| PRJNA590664 | ENA

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [blood]

Project description:We implemented transcriptomic analyses of blood of 8-10M mice; These mice with the treatment of metformin for 30 days.

2020-09-23 | GSE140715 | GEO

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis.

Project description:Metformin is a widely used drug for type 2 diabetes that is considered to have potential anti-aging effects. However, the beneficial effects of metformin in middle-aged normoglycemic mice are less explored. Here, we report that metformin treated by tail vein injection improved cognitive function of aged mice better than oral administration, which seem to show a dose-dependent manner. Correspondingly, long-term oral administration of metformin was associated with significant disability rates. Further, metformin restored cerebral blood flow and brain vascular density and promoted neurogenic potential of the subependymal zone/subventricular zone both in vivo and in vitro. RNA-Seq and q-PCR results indicated that metformin could enhance relative mRNA glycolysis expression in blood and hippocampal tissue, respectively. Mechanistically, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a key enzyme in glycolysis pathway, may contribute to angiogenic and neurogenic potentials of NSCs. Interestingly, the relative GAPDH mRNA expression of peripheral blood mononuclear cell was gradually decreased with aging. Meanwhile its expression level positively correlated with cognitive levels. Our results indicated that metformin represents a candidate pharmacological approach for recruitment of NSCs in aged mouse brain by enhancing glycolysis and promoting neurovascular generation, a strategy that might be of therapeutic value for anti-aging in humans.

| S-EPMC7585073 | biostudies-literature

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-09-23 | GSE140716 | GEO

m6A modification involves in enriched environment-induced neurogenesis and cognition enhancement

Project description:m6A modification involves in enriched environment-induced neurogenesis and cognition enhancement

| PRJNA811978 | ENA

Fetal Growth Restriction Impairs Hippocampal Neurogenesis and Cognition via Tet1 in Offspring

Project description:Fetal Growth Restriction Impairs Hippocampal Neurogenesis and Cognition via Tet1 in Offspring

| PRJNA601762 | ENA

Administration of AGNHW enhances neurogenesis and angiogenesis in a mouse model of experimental cerebral ischemia injury

Project description:Administration of AGNHW enhances neurogenesis and angiogenesis in a mouse model of experimental cerebral ischemia injury

| PRJNA978575 | ENA

Metformin affects transcriptomic pathways involved in cell survival, metabolism and angiogenesis in ovarian cancer cells

Project description:The objectives of the present study are to determine the effect of metformin on sphere formation, extracellular matrix invasion, and transcriptome profile of ovarian cancer (COVCAR) cells isolated from ascites of chickens that naturally developed ovarian cancer. Our results suggest that metformin treatment significantly decreased sphere formation and invasiveness of COVCAR cells. Pairwise statistical analysis of transcriptomic data using Deseq2 software revealed 0, 4, 365 genes that were differentially expressed (DEGs) in cells treated with 0.5, 1, 2 mM metformin-treated cells compared to controls, respectively.

2021-08-17 | GSE182084 | GEO

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