Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional Profiling of Leiomyosarcoma Cell Lines

ABSTRACT: Transcriptional Profiling of Leiomyosarcoma Cell Lines

PROVIDER: PRJNA602391 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10917982.fastq.gz	Fastqsanger.gz
	SRR10917983.fastq.gz	Fastqsanger.gz
	SRR10917984.fastq.gz	Fastqsanger.gz
	SRR10917985.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Transcriptional Profiling of Leiomyosarcoma Cell Lines

Project description:Leiomyosarcoma (LMS) is a mesenchymal neoplasm with complex copy number alterations and characteristic loss of tumor suppressor genes without known recurrent activating oncogenic mutations. Clinical management of advanced LMS relies on cytotoxic chemotherapy and complementary palliative approaches, and research efforts to date have had limited success identifying clinically actionable biomarkers or targeted therapeutic vulnerabilities. To explore the distinctive biological underpinning of LMS, we evaluated gene expression patterns of LMS cell lines and correlated results with primary tumor samples.

2020-01-22 | GSE143968 | GEO

Transcriptional profiling of human MCF7 cell lines by RNASeq

Project description:Transcriptional profiling of human MCF7 cell lines by RNASeq

| PRJNA666627 | ENA

Transcriptional Profiling of CENPA-Depleted Prostate Cancer Cell Lines

Project description:Transcriptional Profiling of CENPA-Depleted Prostate Cancer Cell Lines

| PRJNA525633 | ENA

Transcriptional Profiling of Clonal Cell Lines with Different Circadian Period

Project description:Transcriptional Profiling of Clonal Cell Lines with Different Circadian Period

| PRJNA548677 | ENA

Gene expression profiles of uterine leiomyosarcoma (ULMS)

Project description:Uterine leiomyosarcoma (ULMS) is a poorly understood gynecologic cancer with few effective treatments. This study explores molecular events involved in ULMS with the goal of identifying strategies. Genome-wide transcriptional profiling were used to compare clinically well-annotated specimens of myometrium, leiomyoma and leiomyosarcoma.

2012-04-26 | E-GEOD-36610 | biostudies-arrayexpress

Dataset of transcriptional signature of the MAPK ERK5 in leiomyosarcoma

Project description:Sarcoma, and more specifically leiomyosarcoma, are pathologies with poor prognosis due to the lack of molecular targets and personalised therapeutic approaches. In this context, understanding the molecular bases of these tumors may enable new therapies. Our study investigates the ERK5 kinase activity mediated signaling by comparing RNASeq analysis for genetic inhibition. To do so, a couple of leiomyosarcoma cells lines were abrogated using specific shRNA for ERK5. Total RNA was extracted and sequenced in the DNBSEQ platform and analysed for differentially expressed genes between the conditions.

2025-06-19 | GSE297879 | GEO

Transcriptional profiling of intrahepatic cholangiocarcinoma (iCCA) cell lines transfected with GD3S

Project description:Transcriptional profiling of intrahepatic cholangiocarcinoma (iCCA) cell lines transfected with GD3S

| PRJNA998334 | ENA

Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8⁺ T cell infiltration

Project description:Background: Leiomyosarcomas are among the most common histological types of soft tissue sarcoma (STS), with no effective treatment available for advanced patients. Lung metastasis, the most common site of distant metastasis, is the primary prognostic factor. We analysed the immune environment targeting lung metastasis of STS to explore new targets for immunotherapy. Methods: We analysed the immune environment of primary and lung metastases in 38 patients with STS using immunohistochemistry. Next, we performed gene expression analyses on primary and lung metastatic tissues from six patients with leiomyosarcoma. Using human leiomyosarcoma cell lines, the effects of the identified genes on immune cells were assessed in vitro. Results: Immunohistochemistry showed a significant decrease in CD8⁺ cells in the lung metastases of leiomyosarcoma. Among the genes upregulated in lung metastases, epithelial cellular adhesion molecule (EPCAM) showed the strongest negative correlation with the number of CD8⁺ cells. Transwell assay results showed that the migration of CD8⁺ T cells was significantly increased in the conditioned media obtained after inhibition or knock down of EPCAM. Conclusions: EPCAM was upregulated in lung metastases of leiomyosarcoma, suggesting inhibition of CD8⁺ T cell migration. Our findings suggest that EPCAM could serve as a potential novel therapeutic target for leiomyosarcoma.

2023-12-22 | GSE250089 | GEO

Transcriptional profiling of TSC2-null cell lines UMB1949 and 621-102 (TRI102)

Project description:Transcriptional profiling of TSC2-null cell lines UMB1949 and 621-102 (TRI102)

| PRJNA785449 | ENA

Transcriptional profiling of control versus PAF depleted mouse lung cancer cell lines

Project description:Transcriptional profiling of control versus PAF depleted mouse lung cancer cell lines

| PRJNA562707 | ENA