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Effects of aronia juice consumption on the mRNA expression profile in peripheral blood mononuclear cells in subjects at cardiovascular risk

ABSTRACT: Effects of aronia juice consumption on the mRNA expression profile in peripheral blood mononuclear cells in subjects at cardiovascular risk

PROVIDER: PRJNA605774 | ENA |

REPOSITORIES: ENA

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Effects of aronia juice consumption on the mRNA expression profile in peripheral blood mononuclear cells in subjects at cardiovascular risk

Project description:We aimed to explore the effects of two, high-polyphenol (AMJ) and low-polyphenol (dAMJ), doses of aronia juice (including polyphenol-free placebo, PLB) and their additive effects on whole transcriptome in peripheral blood mononuclear cells (PBMC) of subjects at cardiovascular risk.

2020-05-28 | GSE145034 | GEO

The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk.

Project description:Foods and food products that contain polyphenols are proposed to modulate risk of cardiovascular disease. The aim of this three-arm, crossover, randomized, double-blind, placebo-controlled intervention study was to examine the impact of Aronia melanocarpa juice (AMJ), high-polyphenol (AMJ treatment, 1.17 g/100 mL polyphenols) and low-polyphenol (dAMJ treatment, 0.29 g/100 mL polyphenols) dose, on the transcriptome in peripheral blood mononuclear cells (PBMC) of 19 subjects at cardiovascular risk. Transcriptome data were obtained by microarray. Bioinformatic functional annotation analysis was performed on both the whole transcriptome datasets and the differentially expressed genes (DEGs). Expression of selected DEGs was validated by RT-qPCR. Administration of AMJ and dAMJ treatments during the two consecutive four-week treatment periods had additive effects on PBMC transcriptome profiles, with the most pronounced and specific effect noticed for AMJ in the last treatment period (TP3) of the trial. Between the high-dose and low-dose treatments in TP3, there was a multitude of overlapping DEGs and DEG-enriched biological processes and pathways, which primarily included immunomodulation and regulation of cell proliferation/death. Increased expression of TNF, IL1B, IL8, RGS1, OSM, and DUSP2 in TP3 was confirmed by RT-qPCR. The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-rich aronia juice in individuals at cardiovascular risk.

| S-EPMC7285191 | biostudies-literature

Human Peripheral Blood mononuclear cells from postmenopausal women: grapefruit juice vs. flavanone-free placebo

Project description:Transcriptional profiling of Peripheral Blood mononuclear cells (PBMCs) in apparently healthy postmenopausal women consuming flavanones in grapefruit juice (340 ml/day providing around 210 mg of naringenin glycosides) or flavanone-free placebo drink for 6 months in a cross-over design with a 2-month washout period between consumption of two studied drinks. Goal was to determine the effects of chronic consumption of flavanones in garpefruit juice on global gene expression profiles in humans

2022-05-03 | GSE202084 | GEO

Aronia

Project description:Interindividual differences in the tolerability of aronia juice are associated with changes in the gut microbiome

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Aronia

Project description:Interindividual differences in the tolerability of aronia juice are associated with changes in the gut microbiome

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Aronia arbutifolia

Project description:Aronia arbutifolia

| PRJNA807613 | ENA

Aronia arbutifolia

Project description:Aronia arbutifolia overview

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Organic vegetable juice supplement modulates microbial community in continuous colon simulation system

Project description:In this study, we investigated the effects of organic vegetable juice supplementation on modulating the microbial community, and how its consumption ameliorates blood lipid profiles in diet-induced obese mice. Here, we analyzed the effect of organic vegetable juice on the microbial community and fatty acid synthesis via animal experiments using diet-induced obese mice and continuous colon simulation system. Organic vegetable juice supplement influenced intestinal bacterial composition from phylum to genus level, including decreased Proteobacteria in the ascending colon in the phylum. At the family level, Akkermansia which are associated with obesity, were significantly augmented in the transverse colon and descending colon compared to the control juice group. In addition, treatment with organic vegetable juice affected predicted lipid metabolism function genes related to lipid synthesis. Organic vegetable juice consumption did not have a significant effect on weight loss but helped reduce epididymis fat tissue and adipocytes. Additionally, blood lipid profiles, such as triglyceride, high-density lipoprotein, and glucose, were improved in the organic vegetable juice-fed group. Expression levels of genes related to lipid synthesis, including SREBP-1, PPARγ, C/EBPα, and Fas, were significantly decreased. Analysis of antioxidant markers, including 8-OHdG and MDA, in the vegetable juice group, indicated that blood lipid profiles were improved by the antioxidant effect. These results suggest that organic vegetable juice supplementation may modulate gut microbial community and reduce the potential role of hyperlipidemia in diet-obese mice.

2021-12-31 | GSE171609 | GEO

Study of the Role of Pomegranate Juice Ellagitannins in the Modulation of Inflammation in Inflammatory Bowel Disease

Project description:Aim of this study was to explore the effect of 12-week pomegranate-juice consumption on the global transcriptional profile in individuals with inflammatory bowel disease (IBD) in clinical remission.

2025-05-05 | GSE242140 | GEO

Daily consumption of orange juice modulated intestinal microbiota

Project description:Daily consumption of orange juice modulated intestinal microbiota and improved glucose and lipids metabolism in women: a controlled clinical trial

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