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Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury [scRNA-seq]

ABSTRACT: Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury [scRNA-seq]

PROVIDER: PRJNA605984 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11066900.fastq.gz	Fastqsanger.gz
	SRR11066901.fastq.gz	Fastqsanger.gz
	SRR11066902.fastq.gz	Fastqsanger.gz
	SRR11066903.fastq.gz	Fastqsanger.gz
	SRR11066904.fastq.gz	Fastqsanger.gz

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Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury super

Project description:Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury super

| PRJNA1088486 | ENA

Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury [bulk RNA-seq]

Project description:Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury [bulk RNA-seq]

| PRJNA1088489 | ENA

Hi-C from endothelial cell of hepatic sinusoid (ENCSR982KWR)

Project description:HiC experiment done on endothelial cell of hepatic sinusoid For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2017-10-24 | GSE105988 | GEO

Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury [scRNA-seq]

Project description:Here we profile the transcripts of app. 35.000 single cells isolated from livers of healthy and diseased mice. We show the transcriptomic change associated with fibrosis induction in the non-parenchymal cell types (hepatic stellate cells, liver endothelial cells and macrophages). We reveal a hitherto unknown feature of the HSCs otherwise functionally attributed to the LECs.

2020-08-25 | GSE145086 | GEO

Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.

Project description:Background and aimsHepatic sinusoidal cells are known actors in the fibrogenic response to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and Kupffer cells are responsible for sinusoidal capillarization and perisinusoidal matrix deposition, impairing vascular exchange and heightening the risk of advanced fibrosis. While the overall pathogenesis is well understood, functional relations between cellular transitions during fibrogenesis are only beginning to be resolved. At single-cell resolution, we here explored the heterogeneity of individual cell types and dissected their transitions and crosstalk during fibrogenesis.Approach and resultsWe applied single-cell transcriptomics to map the heterogeneity of sinusoid-associated cells in healthy and injured livers and reconstructed the single-lineage HSC trajectory from pericyte to myofibroblast. Stratifying each sinusoidal cell population by activation state, we projected shifts in sinusoidal communication upon injury. Weighted gene correlation network analysis of the HSC trajectory led to the identification of core genes whose expression proved highly predictive of advanced fibrosis in patients with nonalcoholic steatohepatitis (NASH). Among the core members of the injury-repressed gene module, we identified plasmalemma vesicle-associated protein (PLVAP) as a protein amply expressed by mouse and human HSCs. PLVAP expression was suppressed in activated HSCs upon injury and may hence define hitherto unknown roles for HSCs in the regulation of microcirculatory exchange and its breakdown in chronic liver disease.ConclusionsOur study offers a single-cell resolved account of drug-induced injury of the mammalian liver and identifies key genes that may serve important roles in sinusoidal integrity and as markers of advanced fibrosis in human NASH.

| S-EPMC7820956 | biostudies-literature

Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury [bulk RNA-seq]

2024-03-16 | GSE261720 | GEO

Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury super

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-15 | GSE261721 | GEO

Proteomics analysis of different stages during mouse hepatic ischemia-reperfusion injury

Project description:6-plex TMT-based quantitative proteomics was used to analysis the proteomic profile in different stages of mouse hepatic ischemia-reperfusion injury.

2017-11-23 | PXD007827 | Pride

Transcriptional dynamics of hepatic stellate cells in experimental acute liver injury, liver fibrosis and liver fibrosis reversal.

Project description:Transcriptional alterations during different stages of hepatic stellate cell activation were determined using RNA Sequencing. Models include acute liver injury (1 injection of CCl4) and chronic liver injury (8 injections of CCl4 over 4-week period) with different recovery timepoints. Illumina NextSeq 500 High was used for sequencing.

2021-12-15 | GSE176042 | GEO

scRNA-seq time course of cerebellar Nestin-expressing progenitors from neonatal mice with and without injury at birth

Project description:To investigate the molecular changes that NEP subpopulations endure upon injury and to determine whether specific populations of NEPs have a transient increase in the signaling pathways associated with injury induced cellular stress and ROS, we performed multiplexed scRNA-seq of NEPs (CFP+) isolated by fluorescence activated cell sorting (FACS) from Nes-CFP/+ transgenic neonates with and without irradiation at timepoints P1, P2, P3 and P5.

2024-09-01 | E-MTAB-13353 | biostudies-arrayexpress

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