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To investigate gene expression changes in neurons lacking cap methyltransferase 1 (CMTR1)

ABSTRACT: To investigate gene expression changes in neurons lacking cap methyltransferase 1 (CMTR1)

PROVIDER: PRJNA606450 | ENA |

REPOSITORIES: ENA

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To investigate gene expression changes in neurons lacking cap methyltransferase 1 (CMTR1)

Project description:Transcriptomic profiles of control and CMTR1-knockdown neurons.

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CK2 phosphorylation of cap methyltransferase CMTR1 promotes RNAPII interaction

Project description:CK2 phosphorylation of cap methyltransferase CMTR1 promotes RNAPII interaction

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CK2 phosphorylation of cap methyltransferase CMTR1 promotes RNAPII interaction

Project description:We investigated influence of CMTR1 phosphorylation by CK2 on RNA expression. In this experiment, we added wild-type and phosphorylation deficient mutant of CMTR1 and knocked out the endogenous CMTR1. We demonstrated that lack of phosphorylation of CMTR1 affects only small but specific group of genes.

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CMTR1 is recruited to transcription start sites and has enhanced influence over ribosomal protein and histone genes [RNA-seq]

Project description:We investigated the gene-specificity of mRNA cap methyltransferase CMTR1 and its impact in RNA expression. In this RNA-seq experiment, we used siRNA to knockdown the endogenous CMTR1 protein to investigate its role in mouse embryonic stem cells. We demonstrated that the repression of CMTR1 expression resulted in a loss of RNA expression, particularly of histone and ribosomal protein genes.

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CMTR1 is recruited to transcription start sites and has enhanced influence over ribosomal protein and histone genes [ChIP-seq]

Project description:We investigated the gene-specificity of mRNA cap methyltransferase CMTR1 and its impact in RNA expression. In this ChIP-seq experiment, we investigated the genome-wide chromatin binding profiles of CMTR1 in mouse embryonic stem cells. We demontrated that CMTR1 binds to the transcription start site (TSS) correlating with RNA polymerase II (RNAP II) levels, with predominant binding at histone genes and ribosomal protein (RP) genes. Moreover, the repression of CMTR1 expression resulted in a loss of RNAP II binding at the TSS.

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Project description:Danio rerio cmtr1, cap methyltransferase 1 [Source:NCBI gene;Acc:393102], is expressed in 1 baseline experiment(s);

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Project description:Rattus norvegicus Cmtr1, cap methyltransferase 1 [Source:RGD Symbol;Acc:1307801], is expressed in 7 baseline experiment(s);

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DHX15 regulates CMTR1-dependent gene expression and cell proliferation

Project description:We discovered that the RNA helicase DHX15 is a regulator of the methyltransferase CMTR1. To determine the biological consequences of this interaction we overexpressed CMTR1 or a mutated CMTR1 (2LA)that does not bind DHX15, in the human breast cancer cell line HCC1806. To assess the effects of the DHX15-CMTR1 interaction on translation, polysomes were separated on a sucrose gradient and sequencing libraries generated from the polysomal and input RNA. We found that the DHX15-CMTR1 interaction controls ribosome loading of a subset of mRNAs and impacts on cell proliferation.

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