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Transcriptome analysis of bisphenol A (BPA) treated Y79 human retinoblastoma cells

ABSTRACT: Transcriptome analysis of bisphenol A (BPA) treated Y79 human retinoblastoma cells

PROVIDER: PRJNA609898 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11217910_1.fastq.gz	Fastqsanger.gz
	SRR11217910_2.fastq.gz	Fastqsanger.gz
	SRR11217911_1.fastq.gz	Fastqsanger.gz
	SRR11217911_2.fastq.gz	Fastqsanger.gz
	SRR11217912_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of bisphenol A (BPA) treated Y79 human retinoblastoma cells

Project description:Purpose: finding differential transcripts usage in environmentally harzardous chemical, bisphenol A (BPA) in human retinal cells Methods: transcriptome analysis by the RNA-seq via mRNA pull-down Results: We found that BPA increases cellular toxicity by the increasing of early apoptotic pathway in Y79 cells. Also, over thounds of retained intron events were detected from the RNA-seq analysis. Conclusions: Bisphenol A (BPA) increases early cytotoxic effects in Y79 cells through the early apoptotic pathway and changes the context of trascript through the splicing regulation mechanisms.

2021-02-16 | GSE146255 | GEO

Y79 retinoblastoma cell line secretome

Project description:The proteins secreted from Y79 retinoblastoma cell line were analyzed by the GeLC-MS/MS approach.

2024-01-26 | PXD039515 | Pride

Y79 retinoblastoma cell line surface proteome

Project description:The proteins on the surface of Y79 retinoblastoma cell line were analyzed by cell surface biotinylation and streptavidin affinity purification.

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Gene expression analysis study in curcumin treated and control Y79 cells

Project description:Gene expression analysis study in curcumin treated (20µM curcumin treated Y79 cells) and control Y79 cells (Suspension Y79 cells). Source were Y79 retinoblastoma cell line from human.

2009-07-11 | GSE17034 | GEO

Y79 retinoblastoma cells: control vs. curcumin treated

Project description:miRNA profiling of curcumin treated Y79 cells with untreated Y79 cells (control). Aim of the study to see whether any oncogenes or tumor suppressor genes are regulated on curcumin treatment in Y79 cells.

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Gene expression profiling of retinoblastoma Y79 cell line treated with scopoletin from Morinda citrifolia in vitro

Project description:Retinoblastoma Y79 cell line was treated with scopoletin in vitro and RNA was isolated for microarray experiment to study the changes in the whole gene expression profiling in the Y79 cell line. The study identified 1675 up-regulated genes (>1.0 fold) and 1879 down-regulated genes (<-1 fold) in response to scopoletin treatment

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Whole genome microarray of T lymphoma invasion and metastasis (Tiam1) silenced retinoblastoma Y79 cells

Project description:We hypothesized that Tiam1 is involved in invassiveness of retinoblastoma. The fuctional role of Tiam1 in cell progression and metastasis was tested by siRNA mediated knockdown of Tiam1 in retinoblastoma Y79 cells. The genes de-regulated in response to Tiam1 knockdown was analysed by cDNA microarray in which most of the actin cytoskeleton regulation proteins and apoptotic proteins were de-regulated. our results prove that Tiam1 modulates actin cytoskeleton and cell invasion in retinoblastoma. Retinoblastoma Y79 cells were treated with Tiam1 siRNA for 48hrs and cDNA microarray was performed to analyze the genes regulated by Tiam1 silencing compared to untreated Y79 cells. Experiments were performed in triplicates.

2013-03-31 | E-GEOD-45130 | biostudies-arrayexpress

Gene expression profiling of retinoblastoma Y79 cell line post EpCAM silencing using siRNA

Project description:Retinoblastoma Y79 cell line was treated with specific siRNA to silence EpCAM gene expression in vitro and RNA was isolated for microarray experiment to study the changes in the whole gene expression profiling in the Y79 cell line. The study identified 465 up-regulated genes (>1.0 fold) and 205 down-regulated genes (<0.5 fold) in response to knockdown of Ep-CAM.

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Gene expression profiling of retinoblastoma Y79 cell line grown with scaffold compared to cells without scaffold

Project description:Retinoblastoma Y79 cell line was grown on 3D scaffolds and compared its gene expression profile with Y79 cells grown without scaffold.

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Differential gene expression profile of y79 retinoblastoma cells in response to Anti - HMGA2 siRNA treatment

Project description:The differential gene expression study was conducted in the Anti - HMGA2 siRNA treated Retinoblastoma cell (Y79). The transient transfection in Y79 cells were performed using Anti-HMGA2 siRNA . The concentration and the time of incubation for the transfection was optimised to increase the silencing efficiency and reduce the off -target effects. After 48 hours of transfection the cells were collected and the whole genome cDNA microarray was performed to interpret the differential gene expression regulated by HMGA2 in Y79 cells. The results of the microarray data has been validated.

2012-08-01 | GSE31687 | GEO

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