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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

ABSTRACT: Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

PROVIDER: PRJNA612524 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11305722.fastq.gz	Fastqsanger.gz
	SRR11305723.fastq.gz	Fastqsanger.gz

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

Project description:The proliferative niches in the subpallium generate a rich cellular variety fated for diverse telencephalic regions. The embryonic preoptic area (POA) represents one of these domains giving rise to the pool of cortical GABAergic interneurons and glial cells, in addition to striatal and residual POA cells. The migration from sites of origin within the subpallium to the distant targets like the cerebral cortex, accomplished by the adoption and maintenance of a particular migratory morphology, is a critical step during interneuron development, which seems to be regulated partially via DNA methylation-dependent gene expression. To identify genes that are altered by DNA methylation mediated by DNMT1 in POA-derived Hmx3-positive interneurons, we used an Hmx3-Cre/tdTomato/Dnmt1loxP mouse model and FAC-sorted the basal telencephalon at E16. RNA and MeDIP sequencing were performed. MeDIP data are assigned here.

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons

Project description:Dnmt1 deletion in Hmx3-positive POA-derived interneurons

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

Project description:Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons

Project description:This SuperSeries is composed of the SubSeries listed below.

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [meDIP-seq]

Project description:The emerging role of epigenetic mechanisms like DNA methylation executed by DNA methyltransferases (DNMTs) in synaptic function irrevocably raises the question for the targeted subcellular processes and mechanisms. We here sequenced FAC-sorted PVergic interneurons of 6 month and 18month old PV-Cre/tdTomato/Dnmt1loxp wildtype and knockout mice and performed MeDIP-Seq.

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Project description:The development of cortical circuits, made up of excitatory neurons and inhibitory interneurons, is a fine-tuned and vital process during brain development. Aberrations affecting the establishment of these circuits are implicated in several neuropsychiatric and neurological disorders. While excitatory neurons originate in cortical proliferative zones, inhibitory interneurons migrate from the basal telencephalon into the cortex. This migration is regulated by intrinsic genetic programs and extrinsic cues. Here, we aimed to identify the role of the DNA methyltransferase 1 (DNMT1) in controlling the expression of key genes implicated in the development and migration of post-mitotic somatostatin-positive interneurons as well as its impact on the rest of the cortical population.

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