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Identifying the role of DNMT1 on methylation signatures in somatostatinergic interneurons during embryonic corticogenesis [EM-seq]

ABSTRACT: The establishment of neuronal circuits, made up of excitatory neurons and inhibitory interneurons, is an intricately regulated process during development and is vital for proper brain function. Its perturbations are increasingly implicated in several neuropsychiatric disorders. While excitatory neurons are born in proliferative zones of the cortex, cortical inhibitory interneurons are born in the basal telencephalon and migrate into the cortex. This process is regulated by intrinsic genetic programs as well as extrinsic cues. Here, we aimed to characterize the role of the DNA methyltransferase 1 (DNMT1) in controlling the methylation of key genes implicated in the development and the migration of somatostatin-expressing interneurons within the developing murine cortex.

ORGANISM(S): Mus musculus

PROVIDER: GSE298865 | GEO | 2025/06/18

REPOSITORIES: GEO

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Identifying the role of DNMT1 in gene expression regulation in somatostatinergic interneurons during embryonic corticogenesis [RNA-Seq]

Project description:The establishment of neuronal circuits, made up of excitatory neurons and inhibitory interneurons, is a fine-tuned process during corticogenesis and is pivotal for a functional brain. Developmental aberrations affecting these circuits are implicated in several neuropsychiatric disorders. While excitatory neurons originate in cortical proliferative zones, inhibitory interneurons migrate from the basal telencephalon into the cortex. This migration is regulated by intrinsic genetic programs and extrinsic cues. Here, we aimed to identify the role of the DNA methyltransferase 1 (DNMT1) in controlling the expression of key genes implicated in mouse cortical interneuron development and the migration of somatostatin-expressing interneurons within the developing cortex.

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2020-01-01 | E-MTAB-7879 | biostudies-arrayexpress

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