Transcriptomics

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Identifying the role of DNMT1 in gene expression regulation in somatostatinergic interneurons during embryonic corticogenesis [RNA-Seq]


ABSTRACT: The establishment of neuronal circuits, made up of excitatory neurons and inhibitory interneurons, is a fine-tuned process during corticogenesis and is pivotal for a functional brain. Developmental aberrations affecting these circuits are implicated in several neuropsychiatric disorders. While excitatory neurons originate in cortical proliferative zones, inhibitory interneurons migrate from the basal telencephalon into the cortex. This migration is regulated by intrinsic genetic programs and extrinsic cues. Here, we aimed to identify the role of the DNA methyltransferase 1 (DNMT1) in controlling the expression of key genes implicated in mouse cortical interneuron development and the migration of somatostatin-expressing interneurons within the developing cortex.

ORGANISM(S): Mus musculus

PROVIDER: GSE276516 | GEO | 2025/06/18

REPOSITORIES: GEO

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