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GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate

ABSTRACT: GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate

PROVIDER: PRJNA612620 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11307300_1.fastq.gz	Fastqsanger.gz
	SRR11307300_2.fastq.gz	Fastqsanger.gz
	SRR11307301_1.fastq.gz	Fastqsanger.gz
	SRR11307301_2.fastq.gz	Fastqsanger.gz
	SRR11307302_1.fastq.gz	Fastqsanger.gz

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GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate

Project description:GPD1 overexpression enhances the anti-cancer effect of metformin through synergistic inhibition of mitochondrial function, thereby providing new insight into metformin-mediated cancer therapy.

2020-03-15 | GSE146982 | GEO

Identification and validation of GPD1 as an essential cancer stem cell specific target in glioblastoma (RNA-seq: Gpd1 KO)

Project description:Cancer stem cells (CSCs) are attractive targets for cancer therapy, however, little is known about how to target CSCs without affecting the normal stem cell population. Here we report the ribosome-profiling analysis of mouse neural stem cells and brain tumour stem cells (BTSCs), which leads to the identification of glycerol-3-phosphate dehydrogenase 1 (GPD1) as a CSC- specific determinant. We confirmed that GPD1 is expressed in BTSCs but not in neural stem cells. Intriguingly, expression of GPD1 is only found in the infiltrating dormant BTSCs in vivo and these cells start to divide and drive tumour relapse after chemotherapy. Most importantly, inhibition of GPD1 expression in tumour-bearing mice leads to prolonged survival. Further analysis shows that loss of GPD1 results in widespread changes in important pathways affecting BTSC maintenance. Human patient data analysis suggests that GPD1 is expressed in the dormant infiltrating tumour cells in human glioblastoma and the expression level is associated with a worse prognosis. This study provides an attractive therapeutic target for treating brain tumours and a novel aspect of regulation of CSC dormancy.

2019-07-15 | GSE110868 | GEO

Identification and validation of GPD1 as an essential cancer stem cell specific target in glioblastoma (Ribosome profiling)

2019-07-15 | GSE110866 | GEO

Identification and validation of GPD1 as an essential cancer stem cell specific target in glioblastoma (RNA-seq: NSC vs BTSC)

2019-07-15 | GSE110867 | GEO

Gpd1

Project description:Rattus norvegicus Gpd1, glycerol-3-phosphate dehydrogenase 1 [Source:RGD Symbol;Acc:621381], is expressed in 10 baseline experiment(s);

| ENSRNOG00000056457 | ExpressionAtlas

Gpd1

Project description:Rattus norvegicus Gpd1, glycerol-3-phosphate dehydrogenase 1 [Source:RGD Symbol;Acc:621381], is differentially expressed in 38 experiment(s);

| ENSRNOG00000056457 | ExpressionAtlas

GPD1

Project description:Sus scrofa GPD1, glycerol-3-phosphate dehydrogenase 1 [Source:VGNC Symbol;Acc:VGNC:88583], is differentially expressed in 6 experiment(s);

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gpd1

Project description:Xenopus tropicalis gpd1, glycerol-3-phosphate dehydrogenase 1 [Source:Xenbase;Acc:XB-GENE-1003323], is expressed in 1 baseline experiment(s);

| ENSXETG00000013352 | ExpressionAtlas

GPD1

Project description:Homo sapiens GPD1, glycerol-3-phosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:4455], is differentially expressed in 101 experiment(s);

| ENSG00000167588 | ExpressionAtlas

GPD1

Project description:Homo sapiens GPD1, glycerol-3-phosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:4455], is expressed in 54 baseline experiment(s);

| ENSG00000167588 | ExpressionAtlas

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