Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic Analysis of Equine Placenta Reveals Key Regulators and Pathways Involved in Ascending Placentitis

ABSTRACT: Transcriptomic Analysis of Equine Placenta Reveals Key Regulators and Pathways Involved in Ascending Placentitis

PROVIDER: PRJNA613228 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11343253_1.fastq.gz	Fastqsanger.gz
	SRR11343253_2.fastq.gz	Fastqsanger.gz
	SRR11343254_1.fastq.gz	Fastqsanger.gz
	SRR11343254_2.fastq.gz	Fastqsanger.gz
	SRR11343255_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Decoding the Amniotic Membrane Transcriptome during Equine Ascending Placentitis

Project description:The equine amniotic membrane is a critical barrier to the amniotic compartment and may contribute to surfactant synthesis. To investigate its role in ascending placentitis, we used RNA sequencing, bioinformatics, and immunohistochemistry to analyze gene expression in amniotic membranes from experimentally induced placentitis cases (n = 6) and gestationally matched controls (n = 6). We identified 288 differentially expressed genes (DEGs), with upregulation of TLR4, PTGS2, PTGES, MMP9, CASP3, SOD2, BNIP3, and HMOX1 in placentitis. Immunohistochemistry confirmed protein expression of TLR4 and PTGS2. Functional annotation revealed enrichment in toll-like receptor signaling, suggesting immune activation may impair placental function. These findings highlight the amniotic membrane’s active role in immune response during placentitis.

2025-08-27 | GSE295055 | GEO

Transcriptomic Analysis of Equine Placenta Reveals Key Regulators and Pathways Involved in Ascending Placentitis

Project description:Placentitis was induced in six mares at approximately 290d of gestation (placentitis group), and six mares with gestationally age-matched (290 d) pregnancies did not receive any treatment (control group). For induction of placentitis in the former group, Streptococcus equi subsp. zooepidemicus was introduced intracervically.

2020-11-27 | GSE147161 | GEO

Decoding the Amniotic Membrane Transcriptome during Equine Ascending Placentitis

Project description:Decoding the Amniotic Membrane Transcriptome during Equine Ascending Placentitis

| PRJNA1252718 | ENA

Transcriptomic analysis reveals the key regulators and molecular mechanisms underlying myometrial activation during equine placentitis

Project description:Placentitis was induced in five mares at approximately 290d of gestation (placentitis group), four mares with gestationally age-matched (290 d) pregnancies did not receive any treatment (control group), and the remaining three mares were maintained until approximately 330 d of gestation (prepartum group). For induction of placentitis in the former group, Streptococcus equi subsp. zooepidemicus was introduced intracervically.

2020-04-09 | GSE139986 | GEO

Equine Cervical Remodelling during Prepartum Period and Placentitis: A Transcriptomic Approach (Stroma)

2021-05-08 | GSE162466 | GEO

Equine Cervical Remodelling during Prepartum Period and Placentitis: A Transcriptomic Approach (Mucosa)

2021-05-08 | GSE162465 | GEO

Transcriptomic analysis reveals the key regulators and molecular mechanisms underlying myometrial activation during equine placentitis

Project description:Transcriptomic analysis reveals the key regulators and molecular mechanisms underlying myometrial activation during equine placentitis

| PRJNA587787 | ENA

Equine Cervical Remodelling during Prepartum Period and Placentitis: A Transcriptomic Approach (Stroma)

Project description:Equine Cervical Remodelling during Prepartum Period and Placentitis: A Transcriptomic Approach (Stroma)

| PRJNA681907 | ENA

Equine Cervical Remodelling during Prepartum Period and Placentitis: A Transcriptomic Approach (Mucosa)

Project description:Equine Cervical Remodelling during Prepartum Period and Placentitis: A Transcriptomic Approach (Mucosa)

| PRJNA681906 | ENA

Transcriptomic analysis of equine chorioallantois reveals immune networks and molecular mechanisms involved in nocardioform placentitis.

Project description:Nocardioform placentitis (NP) continues to result in episodic outbreaks of abortion and preterm birth in mares and remains a poorly understood disease. The objective of this study was to characterize the transcriptome of the chorioallantois (CA) of mares with NP. The CA were collected from mares with confirmed NP based upon histopathology, microbiological culture and PCR for Amycolatopsis spp. Samples were collected from the margin of the NP lesion (NPL, n = 4) and grossly normal region (NPN, n = 4). Additionally, CA samples were collected from normal postpartum mares (Control; CRL, n = 4). Transcriptome analysis identified 2892 differentially expressed genes (DEGs) in NPL vs. CRL and 2450 DEGs in NPL vs. NPN. Functional genomics analysis elucidated that inflammatory signaling, toll-like receptor signaling, inflammasome activation, chemotaxis, and apoptosis pathways are involved in NP. The increased leukocytic infiltration in NPL was associated with the upregulation of matrix metalloproteinase (MMP1, MMP3, and MMP8) and apoptosis-related genes, such as caspases (CASP3 and CASP7), which could explain placental separation associated with NP. Also, NP was associated with downregulation of several placenta-regulatory genes (ABCG2, GCM1, EPAS1, and NR3C1), angiogenesis-related genes (VEGFA, FLT1, KDR, and ANGPT2), and glucose transporter coding genes (GLUT1, GLUT10, and GLUT12), as well as upregulation of hypoxia-related genes (HIF1A and EGLN3), which could elucidate placental insufficiency accompanying NP. In conclusion, our findings revealed for the first time, the key regulators and mechanisms underlying placental inflammation, separation, and insufficiency during NP, which might lead to the development of efficacious therapies or diagnostic aids by targeting the key molecular pathways.

| S-EPMC8268225 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data