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Hypoxia-induced genes in mouse spermatogonia

ABSTRACT: Hypoxia-induced genes in mouse spermatogonia

PROVIDER: PRJNA625466 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11548532.fastq.gz	Fastqsanger.gz
	SRR11548533.fastq.gz	Fastqsanger.gz
	SRR11548534.fastq.gz	Fastqsanger.gz
	SRR11548535.fastq.gz	Fastqsanger.gz
	SRR12668169.fastq.gz	Fastqsanger.gz

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Hypoxia-induced genes in mouse spermatogonia

Project description:Purpose: We tried to identify genes that regulate hypoxic response in mouse spermatogonial stem cells. We report the chareacterization of genes expressed under 1% oxygen. Results: We found 228 differentialy expressed genes between cells cultured under hypoxia (1% oxygen) and those under normoxia (20% oxygen).

2021-12-31 | GSE148706 | GEO

Inhibiting neddylation with MLN4924 potentiates hypoxia-induced apoptosis of mouse type B spermatogonia GC-2 cells

Project description:Hypoxia, an inadequate supply of tissue oxygen tension, has been reported to induce apoptosis of spermatogenic cells and is associated with male infertility. Neddylation, a post-translational modification similar to ubiquitination, has been shown to be involved in the hypoxia stress response. However, the functions of neddylation in hypoxia-induced apoptosis of spermatogenic cells and its association with male infertility remain largely unexplored. In this study, aiming to explore the role of neddylation in male infertility, we used the specific neddylation inhibitor MLN4924 for treatment in mouse type B spermatogonia GC-2 cells. Our results showed that MLN4924 had no apparent effect on GC-2 cell apoptosis under normoxia, but significantly increased apoptotic cells under hypoxia. Transcriptomic analysis and qPCR assay confirmed that MLN4924 could suppress the expression of hypoxia target genes in GC-2 cells under hypoxia. In addition, MLN4924 could enhance the induction of intracellular and mitochondrial reactive oxygen species (ROS) under hypoxia. These results indicate that the neddylation inhibitor MLN4924 potentiates hypoxia-induced apoptosis of mouse type B spermatogonia GC-2 cells, and neddylation may play an important role in promoting spermatogenic cells to adapt to hypoxia stress.

2023-11-02 | GSE245989 | GEO

Inhibiting neddylation with MLN4924 potentiates hypoxia-induced apoptosis of mouse type B spermatogonia GC-2 cells

Project description:Inhibiting neddylation with MLN4924 potentiates hypoxia-induced apoptosis of mouse type B spermatogonia GC-2 cells

| PRJNA1030935 | ENA

Transcriptomic analysis of mouse spermatogonia

Project description:Transcriptomic analysis of mouse spermatogonia

| PRJNA649964 | ENA

Hypoxia Induced Pulmonary Hypertension

Project description:Here we investigated the protein composition of the main pulmonary artery (MPA), distal pulmonary arteries (DPA) distal whole lung (DWL) of early stage hypoxia (using a neonatal bovine calf model) and late stage hypoxia (using adult steers with hypoxia-induced PH) using high resolution mass spectrometry. Compartment-resolved analysis allowed for quantitative measurements of proteins from cellular, soluble ECM and insoluble ECM fractions

2022-10-06 | MSV000090482 | MassIVE

Transcriptomic analysis of mouse spermatogonia

Project description:Microarray analysis was performed in order to detail the gene expression profiles in murine b-2M-SPa-6+c-kit-undifferentiated and b-2M-SPa-6+c-kit+ differentiating spermatogonia. These data were used to compare human and mouse transcriptomes of undifferentiated spermatogonia.

2020-08-01 | GSE155507 | GEO

Identification of DDX5 target genes in spermatogonia

Project description:Identification of DDX5 target genes in spermatogonia

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Identification of hypoxia-induced metabolism-associated genes in canine tumors.

Project description:Identification of hypoxia-induced metabolism-associated genes in canine tumors.

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Prepubertal Human Spermatogonia and Mouse Gonocytes Share Conserved Gene Expression of Germline Stem Cell Regulatory

Project description:Full title: Prepubertal Human Spermatogonia and Mouse Gonocytes Share Conserved Gene Expression of Germline Stem Cell Regulatory Molecules Oligonucleotide Microarray Analysis Reveals Novel Genes Expressed in Prepubertal Human Spermatogonia and Mouse Gonocytes

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Identification of DDX5 target genes in spermatogonia

Project description:Sustained spermatogenesis in adult males and recovery of fertility following germ cell depletion are dependent on undifferentiated spermatogonia with self-renewal potential. Self-renewal of undifferentiated spermatogonia is dependent on a complex network of transcriptional and post-transcriptional regulatory factors. DDX5 is known to act as a transcriptional co-regulator in other systems through interactions with key transcription factors. Here, we performed ChIP-Seq to identify target genes of DDX5 in cultured undifferentiated spermatogonia in order to elucidate its role in maintenance of the male germline.

2019-04-02 | GSE110347 | GEO

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