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Memory like NK cells display stem cell like properties after Zika virus infection

ABSTRACT: Memory like NK cells display stem cell like properties after Zika virus infection

PROVIDER: PRJNA625709 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11554155_1.fastq.gz	Fastqsanger.gz
	SRR11554155_2.fastq.gz	Fastqsanger.gz
	SRR11554156_1.fastq.gz	Fastqsanger.gz
	SRR11554156_2.fastq.gz	Fastqsanger.gz
	SRR11554157_1.fastq.gz	Fastqsanger.gz

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Memory like NK cells display stem cell like properties after Zika virus infection

Project description:In this study, we show that CD27+ memory like NK cells generated following Zika virus infection exhibited stem-like features viz., self-renewal pathway, differentiation into effector cells and longer telomeres, and greater therapeutic potential than CD27- and naive CD27+ NK cells when adoptively transferred to Zika virus infected mice. In addition, epigenetic landscape of CD27+ memory like NK is markedly different compared to CD27- NK cells.

2020-12-11 | GSE148780 | GEO

Memory like NK cells display stem cell like properties after Zika virus Infection

Project description:Here we show that Zika virus infection induces memory like NK cells that express CD27. This subset shared transcriptional changes with memory CD8 T cells, stem cells and stem like T cells. These NK cells with memory and stemness features which we term NK memory stem cells (SCMNK) demonstrated greater antiviral potential. Transcriptional data of SCMNK and non-memory NK cells is presented.

2020-12-11 | GSE148205 | GEO

Memory like NK cells display stem cell like properties after Zika virus Infection

Project description:Memory like NK cells display stem cell like properties after Zika virus Infection

| PRJNA623512 | ENA

Memory like NK cells display stem cell like properties after Zika virus infection.

Project description: Not available

| S-EPMC7793296 | biostudies-literature

Quantitative proteomics of cytokine-induced memory-like (CIML) NK cells

Project description:NK cells from healthy donors were isolated from peripheral blood and stimulated overnight with IL-12/15/18 to induce a memory-like phenotype. After 7 days of culture, the phenotype and degranulation potential of CIML NK cells was characterized in two distinct NK cell subsets: CD16+/CD56+ and CD16−/CD56. Finally, NK cell subsets were purified using fluorescence-activated cell sorting (FACS) and subjected to high-throughput multiplexed quantitative proteomics.

2025-07-14 | PXD059190 | Pride

Cytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence Properties

Project description:Recent investigations have indicated that NK cells induced overnight with IL-12/15/18 cytokines possess memory-like characteristics (refers as CIML NK, cytokine induced memory-like NK cells), demonstrating enhanced effector function and prolonged persistence. Preclinical studies and very early clinical trials revealed the promising clinical activity of CIML NK cells in the treatment of hematological malignancies, especially acute myelocytic leukemia (AML). However, the current manufacturing method for CIML NK cells do not endow these cells the ability to expand robustly ex vivo. The low production efficiency limits their clinical application. In this study, we established a novel expansion platform for these memory-like NK cells. This method can effectively and stably expand healthy donor-derived Peripheral NK (PBNK) cells by more than 200-fold within two weeks, with a purity exceeding 95%. Importantly, these ex vivo expanded NK (ExNK) cells exhibited hypomethylated state in the CNS-1 region (Conserved Noncoding Sequence 1) of IFNG gene, stronger metabolic ability, and enhanced effector function when compared to CIML NK cells. Based on these features, we named these expanded NK cells but still possess memory-like characteristics as mExNK (memory-like expanded NK cells). Bulk mRNA-seq further firmly uncovered a high similarity between mExNK and CIML NK cells, with both highly expressing genes being related to proliferation, metabolism, and memory. Furthermore, we also test that these mExNK cells are superior much more than conventional expanded ExNK cells (cExNK). Taken together, the method described herein showed an enhanced expansion efficiency for human memory NK cells and would facilitate their clinic applications in cancer therapy.

2026-06-30 | GSE311121 | GEO

Cytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence Properties

Project description:Cytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence Properties

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RNA expression of memory NK subsets

Project description:we compared and reported RNA expression difference in memory and non-memory NK cell subsets

2020-12-31 | GSE124321 | GEO

RNA expression of memory NK subsets

Project description:RNA expression of memory NK subsets

| PRJNA511658 | ENA

Age influences CMV-specific NK and CD8 T cell memory fates (NK cells)

Project description:Cytomegalovirus (CMV) infection is ubiquitous; though often unnoticed in healthy adults it is a leading cause of neurodisability in neonates/ infants. NK and CD8 T cell cytolysis control CMV; yet their coordinate response to CMV remains uncharacterized, particularly in infants. We interrogated how NK and CD8 T cell responses differed between adults and infants in a murine CMV (MCMV) infection model. NK and CD8 T cells both limited infant MCMV infection morbidity. Notably, adult and infant NK cells effectuate discrete responses to MCMV infection with the latter preferentially forming memory associated with transcriptional distinctions prior to infection. Adoptive transfer studies further revealed that infant T cells are effector-biased but acquire the capacity to form memory in an age-dependent manner. Infant T cells' restricted ability to form memory was associated with a unique transcriptional state before and after infection. Further, acquisition of T cell memory capacity coincided with an age-dependent waning in the induction of adaptive NK cells. Our data suggests non-redundant roles for NK and CD8 T cells in MCMV infection during infancy, as NK cells compensate for the limited establishment of memory T cell subsets.

2026-04-14 | GSE286266 | GEO

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