Project description:To reveal the altered expression profiles of circular RNAs (circRNAs) in the peripheral blood mononuclear cells (PBMCs) of patients with retinopathy of prematurity (ROP), microarray analysis was conducted in the samples from ROP patients and controls.

2022-08-10 | GSE204780 | GEO

Epithelial membrane protein-2 promotes VEGF signaling to promote pathological neovascular growth in retinopathy of prematurity

Project description:Retinopathy of prematurity (ROP) is a leading cause of childhood blindness, and exclusively affects infants born prematurely. In this study, we test the hypothesis that EMP2 contributes to neovascularization in a mouse model of the disease. We show that EMP2 promotes neuronal VEGF signaling and that its downregulation reduces severity of neovascularization.

2021-12-17 | GSE123945 | GEO

Timed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.

Project description:Pathological neovascularization (NV) can cause visual impairment in retinopathy of prematurity (ROP). Current treatments addressing vasoproliferative (Phase II) ROP are costly and can lead to severe complications. We show that well-timed topical 0.1% dexamethasone eye drops during early retinal neovascular formation prevents NV in five extremely preterm infants at high risk for ROP and in mouse oxygen-induced retinopathy (OIR) modeling ROP. In OIR mice, daily treatment before any NV has limited efficacy in mitigating NV, while treatment after peak NV exhibits no statistically significant effect but with a trend to exacerbating NV. Optimally timed topical dexamethasone suppression of NV in OIR is associated with increased retinal mitochondrial gene expression and a decrease in inflammatory markers predominantly expressed in immune cells. This study provides new insights into topical steroid effects in retinal NV and into mitochondrial function in phase II ROP, and suggests a simple approach to preventing severe ROP.

2025-05-07 | PXD052730 | Pride

GENEVA GWAS of Prematurity and its Complications - African Ancestry

Project description:GENEVA GWAS of Prematurity and its Complications - African Ancestry

| PRJNA75465 | ENA

GENEVA GWAS of Prematurity and its Complications - European Ancestry

Project description:GENEVA GWAS of Prematurity and its Complications - European Ancestry

| PRJNA75461 | ENA

Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity

Project description:Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity

| PRJNA901967 | ENA

Project description:Clinical and genetic analysis of retinopathy of prematurity

| PRJNA623135 | ENA