Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transforming Growth Factor-b Suppresses Type 2 Immunity to Cancer

ABSTRACT: Transforming Growth Factor-b Suppresses Type 2 Immunity to Cancer

PROVIDER: PRJNA635688 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11869432_1.fastq.gz	Fastqsanger.gz
	SRR11869432_2.fastq.gz	Fastqsanger.gz
	SRR11869433_1.fastq.gz	Fastqsanger.gz
	SRR11869433_2.fastq.gz	Fastqsanger.gz
	SRR11869434_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

Transforming Growth Factor-b Suppresses Type 2 Immunity to Cancer

Project description:The immune system employs two distinct defense strategies against infections: pathogen elimination typified by type 1 immunity, and pathogen containment exemplified by type 2 immunity concomitant with tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell elimination are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. Here we show that ablation of transforming growth factor-β receptor II (TGFβRII) in CD4+ T cells promotes tumor tissue healing and halts cancer progression. The restorative response is associated with remodeling of the blood vasculature patterning with cancer cell hypoxia and death instigated in avascular regions, a process dependent on the T helper 2 cytokine IL-4. Thus, type 2 immunity represents an effective cancer defense mechanism, and TGFβ signaling in helper T cells may be targeted for tissue-level cancer immunotherapy.

2020-05-29 | GSE151406 | GEO

Transforming growth factor beta signaling and decidual development in mice

Project description:Transforming growth factor beta signaling and decidual development in mice

| PRJNA646519 | ENA

Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1

Project description:Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1

| PRJNA594298 | ENA

Expression data from A549 cells after treatment with flagellin and transforming growth factor beta 1

2012-10-31 | GSE38309 | GEO

Expression data from A549 cells after treatment with flagellin and transforming growth factor beta 1

Project description:We have examined the changes in gene expression aftert reatment of A549 cells, a cultured alveolar epithelial cells, with flagellin and transforming growth factor beta 1. In this dataset, we include the expression data obtained from A549 cells after treatment with purified flagellin or transforming growth factor beta 1 receptor. The analysis indicated that flagellin induced a change in gene expression that was similar to the changes induced by transforming growth factor 1. A549 cells were treated with flagellin or transforming growth factor 1 for 24 h. Total RNA was extracted and reverse transcribed to cDNA. Synthesized cDNA was fragmented and labeled with biotin. The biotinylated cDNA was hybridized to to an Affymetrix GeneChip Array, and probe signal intensities were captured.

2012-10-31 | E-GEOD-38309 | biostudies-arrayexpress

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts

Project description:Transforming growth factor beta 1 induces methylation changes in lung fibroblasts

| PRJNA557426 | ENA

Spleen vs TGF-beta (transforming growth factor-beta) Treated B cell

Project description:total RNA from mouse (male c57BL/6) spleen labeled with Cy3 vs total RNA from mouse (male c57BL/6) B cells treated with TGF-beta (transforming growth factor-beta) labeled with Cy5- time course with repeats Keywords: ordered

2003-04-14 | GSE400 | GEO

Transforming growth factor-B1 drives differentiation of the embryonic jejunum

Project description:Transcription profiling by microarray was performed to pinpoint the roles of transforming growth factor B1 (TGFB1) in embryonic differentiation of the small intestine. An organ culture system in which mouse jejunal rudiments were placed on semipermeable platforms and fed with chemically defined serum-free media, supplemented with two concentrations of TGFB1.

2017-04-03 | E-MTAB-4509 | biostudies-arrayexpress

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts [Illumina]

Project description:Transforming growth factor beta 1 induces methylation changes in lung fibroblasts [Illumina]

| PRJNA557428 | ENA

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts [Affymetrix]

Project description:Transforming growth factor beta 1 induces methylation changes in lung fibroblasts [Affymetrix]

| PRJNA557430 | ENA