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RNA seq data of CD8+ T cells in peripheral blood lymphocytes from melanoma and lung cancer patients

ABSTRACT: RNA seq data of CD8+ T cells in peripheral blood lymphocytes from melanoma and lung cancer patients

PROVIDER: PRJNA639802 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12024908.fastq.gz	Fastqsanger.gz
	SRR12024909.fastq.gz	Fastqsanger.gz
	SRR12024910.fastq.gz	Fastqsanger.gz
	SRR12024911.fastq.gz	Fastqsanger.gz
	SRR12024912.fastq.gz	Fastqsanger.gz

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CD8+ T cells in peripheral blood lymphocytes and tumor-infiltrating lymphocytes of melanoma patients

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RNA seq data of CD8+ T cells in peripheral blood lymphocytes from melanoma and lung cancer patients

Project description:CD8+ T cells are the primary target of immune checkpoint inhibitor (ICI) therapy in the treatment of cancers. ICI therapy only benefits a subset of patients and complicating this issue is a reliable prediction method that does not require invasive biopsies. We built an ICI response prediction model using scRNA seq data, and for validation of the model here we profiled transcriptome of CD8+ T cells in peripheral blood lymphocytes of 4 melanoma and 4 lung cancer patients that responded to ICI or not using RNA sequencing.

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Project description:Bulk RNA seq profile of CD8+ T cells in peripheral blood lymphocytes from 28 melanoma patients

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Gene expression profile of peripheral blood lymphocytes: comparison between melanoma patients and healthy controls

Project description:We focused on the major peripheral blood lymphocyte populations that may be involved in anti-tumor responses and negatively impacted by cancer, specifically CD8 T cells, CD4 T cells, B cells and CD56dim natural killer cells. The pure cell subsets were stringently sorted by flow cytometry from PBMC samples. Gene expression profiles of these cell populations from melanoma patients were compared to healthy controls. Keywords: gene expression profile

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