Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Exosome miRNA Profile of canine oral melanoma

PROVIDER: PRJNA656859 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12448036_1.fastq.gz	Fastqsanger.gz
	SRR12448036_2.fastq.gz	Fastqsanger.gz
	SRR12448037_1.fastq.gz	Fastqsanger.gz
	SRR12448037_2.fastq.gz	Fastqsanger.gz
	SRR12448038_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Development and characterization of two canine melanoma cell lines with distinct clinical profiles: new models for comparative oncology

Project description:In order to develop a new canine model of melnoma, we isolated and characterised three cell lines from oral canine malignant melanoma samples obtained from patients presenting distinct clinical behavior

2019-02-27 | GSE88724 | GEO

Project description:Small RNA profile of canine oral melanoma

| PRJNA516252 | ENA

Utilizing MALDI-TOF mass spectrometry and liquid chromatography-tandem mass spectrometry to access serum peptidome-based biomarkers in canine oral tumors

Project description:Tumors frequently found in dogs include canine oral tumors, either cancerous or noncancerous. The bloodstream is an important route for tumor metastasis, particularly for late-stage oral melanoma (LOM) and late-stage oral squamous cell carcinoma (LOSCC). The present study aimed to investigate serum peptidome-based biomarkers of dogs with early-stage oral melanoma, LOM, LOSCC, benign oral tumors, chronic periodontitis and healthy controls, using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and liquid chromatography tandem mass spectrometry.

2023-09-28 | PXD037051 | JPOST Repository

MicroRNA profiling by array of canine oral malignant melanoma and paired normal oral mucosa samples

Project description:total RNAs were extracted from a canine oral malignant melanoma clinical sample (name as 3) and paired normal oral mucosa (name as 3prime) according to the phenol/guanidium thiocyanate method with DNase â treatment. these total RNA were submitted to Filgen, Inc. to perform microRNA microarray.

2011-10-21 | E-MTAB-405 | biostudies-arrayexpress

Project description:Canine oral melanoma genomic study

| PRJNA779870 | ENA

Project description:Canine oral melanoma genomic study

| PRJNA780881 | ENA

Project description:Canine oral melanoma transcriptomic study

| PRJNA749900 | ENA

Project description:Canine oral melanoma genomic study

| PRJNA786469 | ENA

Project description:mRNA-Seq of Canine oral melanoma

| PRJNA527141 | ENA

Stromal expression profiling reveals immune-driven adaption to malignancy in canine melanoma subtypes

Project description:Canine mucosal melanoma (CMM) is the most common oral malignancy in dogs and exhibits significantly higher aggressiveness than its cutaneous counterpart (CCM), yet the reasons for this disparity remain unclear. The influence of cancer-associated stroma (CAS) on tumour progression is well-recognized, but a detailed understanding of CAS in canine melanoma is missing. To comprehensively assess stromal reprogramming in canine melanoma, we analysed CAS from 21 CMM, 14 CCM and normal stroma from 10 skin and 9 oral mucosa samples by laser-capture microdissection followed by RNA sequencing. Results were assessed in relation to subtypes, prognostic factors including mitotic count (MC), ulceration, necrosis, pigmentation, and immune cell infiltration (CD3, CD20 and CD68), scored using immunohistochemistry. While stromal reprogramming was evident in both subtypes, it was significantly more pronounced in CMM. Furthermore, MC strongly correlated with stromal gene expression in both subtypes, suggesting CAS reprogramming to depend on tumour malignancy. Comparison of subtypes revealed specific downregulation of key regulators of leukocyte activation and proliferation in mucosal CAS, supporting a role for impaired immune control in CMM aggressiveness. CMM presented with significantly more CD20 infiltrated (excluded or hot) cases than CCM. In CMM, CD20 infiltration was significantly associated with MC, with excluded cases displaying highest MC. Finally, we identify an immune-suppressive stromal signature in a subset of CMM that influences tumour aggressiveness and predicts overall survival in human melanoma patients. Together, these findings provide a solid foundation for understanding the role of CAS in canine melanoma, with relevance for the human disease.

2024-05-31 | GSE266234 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data