Project description:mRNA microarrays were performed to identify changes in mRNA expression between 8-week-old and 28-week-old NZBWF1 mice. 1796 mRNAs were identified as being significantly differentially expressed.
Project description:miRNA microarrays were performed to identify changes in miRNA expression between 8-week-old and 28-week-old NZBWF1 mice. 43 miRNAs were identified as being significantly differentially expressed.
Project description:Differential gene expression profiling of conventional (Tconv), regulatory (Treg), follicular (TFH) helper and follicular regulatory (TFR) T-cells from control vs OX40L-Jagged-1 treated NZBWF1/j mice
Project description:Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by failure of self-tolerance mechanisms and the resultant production of autoreactive antibodies. The NZBWF1 mouse spontaneously develops a lupus-like syndrome and is used as model of SLE. The NZBWF1 model represents the F1 generation of a cross between New Zealand Black (NZB) and New Zealand White (NZW) mice. In this study we investigated the model and its progenitors (NZB, NZW) gene expression with single cell RNA sequencing on cells isolated from bone marrow and processed with the 10X Chromium.
Project description:This dataset comprises analysis data obtained from the kidney tissues of six mice with sepsis induced by intraperitoneal injection of lipopolysaccharide (LPS) (n=6), as well as six mice with kidney injury secondary to sepsis (n=6). The kidney tissues were harvested 24 hours post the establishment of the mouse models, and subsequent sequencing was conducted utilizing mass spectrometry technology.
Project description:O-GlcNAcylation is a global post translational modification. The purpose of this study is to investigate the role of O-GlcNAcylation in mice kidney proximal tubules. We used drug-inducible proximal tubular cells specific O-GlcNAc transferase (Ogt) KO mice (PTEC-Ogt KO). In this proteomic analysis, we compared kidney cortex from fasted PTEC-Ogt KO and Control mice.