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Gene expression differences among Neuropilin1 (NRP1) knockdown cell lines

ABSTRACT: Gene expression differences among Neuropilin1 (NRP1) knockdown cell lines

PROVIDER: PRJNA662375 | ENA |

REPOSITORIES: ENA

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Gene expression differences among Neuropilin1 (NRP1) knockdown cell lines

Project description:To further find out candidates down or up regulated by Neuropilin1(NRP1)

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Project description:Obesity gives rise to metabolic complications by mechanisms that are poorly understood. While chronic inflammatory signaling in adipose tissue is typically associated with metabolic deficiencies linked to excessive weight gain, we identified a subset of NRP1-expressing myeloid cells that accumulate in adipose tissue and protect against obesity and metabolic syndrome. Ablation of NRP1 in macrophages compromised lipid uptake in these cells, which reduced substrates for fatty acid β-oxidation and shifted energy metabolism of these macrophages towards a more inflammatory glycolytic metabolism. Conditional deletion of NRP1 in LysM Cre-expressing cells lead to inadequate adipose vascularization, accelerated weight gain and reduced insulin sensitivity even independent of weight gain. Transfer of NRP1+ hematopoietic cells improved glucose homeostasis, resulting in the reversal of a prediabetic phenotype. Our findings suggest a pivotal role for adipose tissue resident NRP1+-expressing macrophages in driving healthy weight gain and maintaining glucose tolerance.

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RNA Sequencing dataset of Claudin-low Breast Cancer Cell Lines with Neuropilin-1 Knockdown

Project description:Triple-negative breast cancers (TNBC) are a particularly aggressive breast cancer subtype with poor prognosis and high relapse rates. Due to a lack of identified targeted therapies, chemotherapy currently remains as the primary treatment for TNBC. Approximately 25-39% of TNBC are claudin-low breast cancers, which are mainly defined by low expression of cell-cell adhesion proteins and enrichment of mesenchymal signatures. Functional studies have demonstrated the potential role of the transmembrane-coreceptor, Neuropilin-1 (NRP1) in regulating the progression of these tumours. However, there have been no high-throughput studies to date that comprehensively investigate NRP1-modulated cell signalling across multiple claudin-low cell lines. Therefore, we knocked-down NRP1 by two small-interfering RNA (siRNA) or two short-hairpin RNA (shRNA) sequences in each of HS578T, MDA-MB-231 and SUM159PT claudin-low cell lines and followed this with Bulk-RNA sequencing. We present this comprehensive transcriptomic data set which provides a valuable resource for the analysis of NRP1-regulated signalling pathways in claudin-low breast cancer, paving the way for future studies of its potential as a targeted therapeutic.

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