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ABSTRACT: Human Microbiome in Adults and Children with Chronic Rhinosinusitis

PROVIDER: PRJNA668045 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12793936_1.fastq.gz	Fastqsanger.gz
	SRR12793936_2.fastq.gz	Fastqsanger.gz
	SRR12793937_1.fastq.gz	Fastqsanger.gz
	SRR12793937_2.fastq.gz	Fastqsanger.gz
	SRR12793938_1.fastq.gz	Fastqsanger.gz

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Project description:Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS). However, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS.We analyzed the effects of antibiotics on the nasal secreted proteome inthe context of CRS using data-independent acqusition proteomics approach.

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CC10 gene deletion: Effect on gene expression in the sinonasal mucosa

Project description:Comparative analysis of gene expression in murine sinonasal mucosa in wild-type and CC10-knockout littermates with allergic eosinophilic chronic rhinosinusitis. The data provide a comprehensive overview of genes expressed in the mouse sinonasal mucosa and show that the expression of several known and unidentified genes is modified by disruption of the CC10 gene. Total RNA isolated from sinonasal mucosae of 6- to 8-week-old mice, C57BL/6 strain, was used for this comparison. Three groups: wild-type control, wild-type with allergic eosinophilic chronic rhinosinusitis, and CC10-knockout with allergic eosinophilic chronic rhinosinusitis.

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Project description:Alterations of nasal microbiome in eosinophilic chronic rhinosinusitis

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