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RNMT regulates the CD4 T cell transcriptome and translatome

ABSTRACT: RNMT regulates the CD4 T cell transcriptome and translatome

PROVIDER: PRJNA672947 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12925916_1.fastq.gz	Fastqsanger.gz
	SRR12925916_2.fastq.gz	Fastqsanger.gz
	SRR12925917_1.fastq.gz	Fastqsanger.gz
	SRR12925917_2.fastq.gz	Fastqsanger.gz
	SRR12925918_1.fastq.gz	Fastqsanger.gz

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RNMT regulates the activated CD4 T cell transcriptome and translatome [Ribo-Seq]

Project description:We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These ribosome footprinting experiments investigate the effect of Rnmt cKO on the activated CD4 T cell transcriptome and translatome.

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RNMT regulates the naïve CD4 T cell transcriptome

Project description:We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These RNAseq experiments investigate the effect of Rnmt cKO on the naïve CD4 T cell transcriptome.

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Rnmt cKO vs control activated CD4 T cell ribo Mega-SEC

Project description:We aimed to identify how loss of the cap methyltransferase RNMT affected the ribosomes and ribosome-associated proteins in activated CD4 T cells.

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RNMT regulates the CD4 T cell transcriptome and translatome

Project description:This SuperSeries is composed of the SubSeries listed below.

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