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Conjoint Analysis of Metabolome and Transcriptome Reveals the Difference in Flavonoid Biosynthesis in Two Pomelo Cultivars

ABSTRACT: Conjoint Analysis of Metabolome and Transcriptome Reveals the Difference in Flavonoid Biosynthesis in Two Pomelo Cultivars

PROVIDER: PRJNA683589 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13217246_1.fastq.gz	Fastqsanger.gz
	SRR13217246_2.fastq.gz	Fastqsanger.gz
	SRR13217247_1.fastq.gz	Fastqsanger.gz
	SRR13217247_2.fastq.gz	Fastqsanger.gz
	SRR13217248_1.fastq.gz	Fastqsanger.gz

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Conjoint Analysis of Metabolome and Transcriptome Reveals the Difference in Flavonoid Biosynthesis in Two Pomelo Cultivars

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Integrated Analysis of Metabolome and Transcriptome Reveals the Difference in Flavonoid Biosynthesis between the Red- and White-Sarcocarp Pomelo Fruits.

Project description:Flavonoids are bioactive secondary metabolites that play multiple roles in plants. However, studies on the flavonoid accumulation of the pomelo fruit are rare. In this study, we conducted a widely targeted metabolome analysis by using ultra-performance liquid chromatography and tandem mass spectrometry and identified 550 metabolites in the sarcocarp from red (C. maxima Merr. var. Tubtim Siam) and white pomelos (C. maxima (Burm.) Osbeck). A total of 263 significantly changed metabolites were detected from the 550 metabolites. Content analysis of the significantly changed metabolites (SCMs) showed that 138 SCMs were highly accumulated, whereas 125 SCMs were observed with lower content in red-sarcocarp pomelo. Importantly, 103 of the 263 SCMs were flavonoids, including 34 flavonoids, 29 flavonols, 18 flavonoid carbonosides, 9 dihydroflavones, 6 isoflavones, 5 anthocyanins, 1 dihydroflavonol, and 1 chalcone. Gene ontology analysis indicated that upregulated genes in red-sarcocarp pomelo were significantly enriched in GO terms related to flavonoids including flavonoid biosynthetic processes. Several important differentially expressed genes were detected in the correlation network, especially Cg2g009540 which is an orthologous gene of AtCHS, also detected in flavonoid biosynthesis networks, and which could be related to the high level of total flavonoids in the red-sarcocarp pomelo. Our study demonstrated the fluctuation of flavonoid biosynthesis in the two pomelo cultivars and laid a theoretical foundation for pomelo breeding to generate fruits with a high flavonoid content.

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