Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of NRF2 in the effects of methionine restriction on the transcriptome of mouse livers

ABSTRACT: The role of NRF2 in the effects of methionine restriction on the transcriptome of mouse livers

PROVIDER: PRJNA683939 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13234400.fastq.gz	Fastqsanger.gz
	SRR13234401.fastq.gz	Fastqsanger.gz
	SRR13234402.fastq.gz	Fastqsanger.gz
	SRR13234403.fastq.gz	Fastqsanger.gz
	SRR13234404.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

The role of NRF2 in the effects of methionine restriction on the transcriptome of mouse livers

Project description:Dietary methionine restriction results in a robust activation of transcription factor, NRF2, and its target gene expression in the liver. In the current study, we observed liver-specific knockout NRF2 did not affect the physiological responses due to MR consumption. Therefore, there are other transcription factors compensate for the loss of NRF2 in the liver to mediate the effect of MR. The RNAseq experiment was comducted to compare the effect of MR diet in NRF2 WT and KO mice on hepatic transcriptome.

2021-06-30 | GSE162964 | GEO

scRNA-seq of aged Drosophila midgut under methionine restriction

Project description:Methionine restriction is known to extend lifespan in various model organisms including Drosophila melanogaster. In this analysis, we performed scRNAseq of Drosophila female midgut samples to understand the cell type specific response to methionine restriction.

2023-09-25 | GSE198149 | GEO

Effects of 20 months Dietary Methionine Restriction on Hepatic Gene Expression in Fischer 344 Rats

Project description:Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the liver. We analyzed MR-induced changes in gene expression using pooled RNA from liver of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

2012-04-07 | E-GEOD-28482 | biostudies-arrayexpress

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response

Project description:Methionine restriction sensitizes A549 cells with and without LKB1 to chemotherapy

2024-07-19 | GSE270333 | GEO

Effects of 20 months Dietary Methionine Restriction on Gene Expression in inguinal white adipose tissue of Fischer 344 Rats

Project description:Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the inguinal white adipose tissue (IWAT). We analyzed MR-induced changes in gene expression using pooled RNA from IWAT of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

2013-07-01 | E-GEOD-28599 | biostudies-arrayexpress

Effects of 20 months Dietary Methionine Restriction on Hepatic Gene Expression in Fischer 344 Rats

2012-04-08 | GSE28482 | GEO

Effects of Oltipraz on Gene Expression in the Livers of Wild-Type and Nrf2-null Mice

Project description:Oltipraz is an activator of Nrf2 but is also an activator of other pathways including those mediated by constitutive activated receptor (CAR). To identify genes regulated by oltipraz that were Nrf2-dependent, we compared gene expression after exposure in wild-type and Nrf2-null mice. Wild-type or Nrf2-null mice were treated each day for 4 days with 75 mg/kg/day/day oltipraz in corn oil or corn oil alone. There were 4 biological replicates used for each of the 4 genotype-treatment groups. Gene expression in the livers of the mice was evaluated using Affymetrix mouse exon arrays (MoEx-1_0-st-v1).

2016-08-16 | E-GEOD-85222 | biostudies-arrayexpress

The effect of dietary methionine restriction using different protein sources on the transcriptome of mouse livers

Project description:The effect of dietary methionine restriction using different protein sources on the transcriptome of mouse livers

| PRJNA706191 | ENA

Gene expressions in Atg7- and Atg7 Nrf2-deficient livers

Project description:Nrf2-dependent expression of numerous genes in Atg7-deficient livers was observed.

2016-06-21 | GSE65174 | GEO

Gene expression profiles in livers caused by Atg7 and/or Nrf2 deficiency

Project description:Autophagy deficiency caused by conditional knockout of Atg7 results in severe hepatitis accompanied by abundant accumulation of p62. p62 stablizes Nrf2 by disrupting the association between Keap1 and Nrf2. To understand the pathogenesis of hepatitis under the autophagy deficiency, we examined gene expression profiles of livers from Atg7-null, Nrf2-null and Atg7-Nrf2 double mutant mice. Eight week old Atg7F/F:Mx1-Cre mice and Atg7F/F:Mx1-Cre:Nrf2-/- together with control mice were injected with pIpC. At 4 weeks after pIpC injection, total RNAs were purified from each mouse liver.

2010-10-14 | E-GEOD-20415 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data