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Gene expression profiles in GC B cells during acute and chronic viral infection

ABSTRACT: Gene expression profiles in GC B cells during acute and chronic viral infection

PROVIDER: PRJNA685826 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13261434.fastq.gz	Fastqsanger.gz
	SRR13261435.fastq.gz	Fastqsanger.gz
	SRR13261436.fastq.gz	Fastqsanger.gz
	SRR13261437.fastq.gz	Fastqsanger.gz
	SRR13261438.fastq.gz	Fastqsanger.gz

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Gene expression profiles in GC B cells during acute and chronic viral infection

Project description:To study how chronic viral infection disrupts B cell differentiation pathways and identify key intrinsic regulators in an endogenous polyclonal response, we used the comparative LCMV model. Wild-type mice were infected with either the acute (WE) versus chronic (Docile) strains of LCMV, GC B cells (CD19+IgDloCD95+CD38loCD138-) isolated 14 days post-infection, and RNA-seq was undertaken

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Project description:Regulatory T (Treg) cells act as terminators in the case of T cell immunity during the acute phase of viral infection. However, their roles in chronic viral infection are not completely understood. We compared the phenotype and function of Treg cells during acute and chronic viral infection using lymphocytic choriomeningitis virus-infected mouse models. Chronic infection, unlike acute infection, led to induction of Treg cells and upregulation of various inhibitory receptors. Treg cells isolated from chronically infected mice (chronic Treg cells) displayed greater suppressive capacity for inhibiting T cell proliferation and subsequent cytokine production than those from naïve (naive Treg cells) or acutely infected mice (acute Treg cells). These gene expression profiles provided evidence that chronic Treg cells display characteristics distinct from either naive or acute Treg cells.

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