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Gene expression profiles in GC B cells of wild-type and Bmi1 cKO mice during acute or chronic viral infection

ABSTRACT: Gene expression profiles in GC B cells of wild-type and Bmi1 cKO mice during acute or chronic viral infection

PROVIDER: PRJNA756449 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15534409.fastq.gz	Fastqsanger.gz
	SRR15534410.fastq.gz	Fastqsanger.gz
	SRR15534411.fastq.gz	Fastqsanger.gz
	SRR15534412.fastq.gz	Fastqsanger.gz
	SRR15534413.fastq.gz	Fastqsanger.gz

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Gene expression profiles in GC B cells of wild-type and Bmi1 cKO mice during acute or chronic viral infection

Project description:To study how chronic viral infection disrupts B cell differentiation pathways and identify key intrinsic regulators in an endogenous polyclonal response, we used the comparative LCMV model. Wild-type or Bmi1 conditional know-out in B cells mice were infected with either the acute (WE) versus chronic (Docile) strains of LCMV, GC B cells (CD19+IgDloCD95+CD38loCD138-) isolated 14 days post-infection, and RNA-seq was undertaken

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