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3D genomics across the tree of life reveals condensin II as a determinant of architecture type [RNA-Seq]

ABSTRACT: 3D genomics across the tree of life reveals condensin II as a determinant of architecture type [RNA-Seq]

PROVIDER: PRJNA686986 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13282025.fastq.gz	Fastqsanger.gz
	SRR13282026.fastq.gz	Fastqsanger.gz
	SRR13282027.fastq.gz	Fastqsanger.gz
	SRR13282028.fastq.gz	Fastqsanger.gz
	SRR13282029.fastq.gz	Fastqsanger.gz

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Similar Datasets

3D genomics across the tree of life reveals condensin II as a determinant of architecture type [RNA-Seq]

Project description:We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.

2021-04-26 | GSE163640 | GEO

3D genomics across the tree of life reveals condensin II as a determinant of architecture type [Hi-C]

2021-04-26 | GSE163625 | GEO

3D genomics across the tree of life reveals condensin II as a determinant of architecture type [DamID-seq]

2021-04-26 | GSE163626 | GEO

3D genomics across the tree of life reveals condensin II as a determinant of architecture type

Project description:3D genomics across the tree of life reveals condensin II as a determinant of architecture type

| PRJNA686983 | ENA

3D genomics across the tree of life reveals condensin II as a determinant of architecture type

Project description:We investigated genome folding across the eukaryotic tree of life. We find four general manifestations of genome organization at chromosome-scale that each emerge and disappear repeatedly over the course of evolution. The submission represents chromosome-length Hi-C contact maps, architecture type and homolog separation analyses for 26 species across the tree of life, representing all subphyla of chordates, all 7 extant vertebrate classes, and 7 out of 9 major animal phyla, as well as plants and fungi.

2021-04-23 | GSE169088 | GEO

3D genomics across the tree of life reveals condensin II as a determinant of architecture type [Hi-C]

Project description:3D genomics across the tree of life reveals condensin II as a determinant of architecture type [Hi-C]

| PRJNA686959 | ENA

3D genomics across the tree of life reveals condensin II as a determinant of architecture type [DamID-seq]

Project description:3D genomics across the tree of life reveals condensin II as a determinant of architecture type [DamID-seq]

| PRJNA686962 | ENA

3D genomics across the tree of life reveals condensin II as a determinant of architecture type.

| S-EPMC8172041 | biostudies-literature

3D genomics across the tree of life reveals condensin II as a determinant of architecture type

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-26 | GSE163641 | GEO

M18BP1 is a determinant of Condensin II activation

Project description:Condensin I and Condensin II promote drastic spatial compaction (condensation) of the genome upon mitotic entry. Condensin I binds chromatin only after dissolution of the nuclear envelope in prophase. Conversely, Condensin II is nuclear throughout the cell cycle and initiates chromosome condensation. Previous studies demonstrated that MCPH1 inhibits Condensin II to prevent chromosome condensation during interphase. Mechanisms that promote Condensin II activation in early mitosis likely exist but are currently unknown. Through genetic and proteomic approaches, we identify M18BP1, a protein previously associated with centromere identity, as a factor required for Condensin II localization to chromatin during mitosis. To activate and localize Condensin II, M18BP1 directly binds the CAP-G2 subunit. M18BP1 and MCPH1 compete for CAP-G2 binding, and CDK1 phosphorylation promotes replacement of MCPH1 with M18BP1 to activate Condensin II upon mitotic entry. Our results identify a fundamental and evolutionarily conserved mechanism of Condensin II activation

2025-11-03 | PXD051556 | Pride

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