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ACAA2 genome-binding patterns before and after transverse aortic constriction in C57Bl/6J mice on different diets [ACAA2]

ABSTRACT: ACAA2 genome-binding patterns before and after transverse aortic constriction in C57Bl/6J mice on different diets [ACAA2]

PROVIDER: PRJNA693864 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13500351.fastq.gz	Fastqsanger.gz
	SRR13500352.fastq.gz	Fastqsanger.gz
	SRR13500353.fastq.gz	Fastqsanger.gz
	SRR13500354.fastq.gz	Fastqsanger.gz
	SRR13500355.fastq.gz	Fastqsanger.gz

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ACAA2 genome-binding patterns before and after transverse aortic constriction in C57Bl/6J mice on different diets [ACAA2]

Project description:Acetyl-CoA acyltransferace 2 (ACAA2) associates with chromatin at promoter sites in the heart of C57Bl/6J mice. A high-fat vs. low-fat diet reduces it promoter abundance, whereas, transverse aortic constriction (TAC) increases it slight.

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The effect of diet on H3K9-butyryl and H3K9-acetyl in the heart before and after transverse aortic constriction in C57Bl/6J mice

Project description:Mice (C57Bl/6J) that are fed increasing levels of dietary fat (0, 10, and 60 Kcal%) show a parallel increasing decline in global promoter-H3K9-butyryl (H3K9Bu), but none in promoter-H3K9-acetyl (H3K9ac), in the heart. Additionally, transverse aortic constriction (TAC) induces a further decline in H3K9Bu, compared to an increase in H3K9ac.

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Gene expression following transverse aortic constriction in mice housed under normoxic or hypoxic conditions

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The effect of transverse aortic constriction on gene expression in Balb/cJ versus Balb/cByJ(∆ACADS) mice hearts

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Phosphoproteomic Analysis Reveals Molecular Signatures of Myocardial Infarction and Transverse Aortic Constriction in Aged Mouse Models

Project description:Project description: In this study, we performed proteome analyses to identify the key molecules that participate in aged mouse models of MI and transverse aortic constriction (TAC), the latter of which mimics increased left ventricular afterload that in the clinical setting predominantly occurs owing to aortic stenosis or systemic hypertension. B11 represents the tissues of an aged MI mouse. B17 represents the tissues of an aged TAC mouse. B15 represents the tissues of an aged Sham mouse.

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RNA-seq data in cardiac tissues from cardiomyocyte-specific Acsl4 knockout mice after transverse aortic constriction

Project description:In order to investigate the differentially expressed genes in Acsl4 knockout after TAC (Transverse aortic constriction) or sham surgery. The experiment was divided to four groups including sham-operated Acsl4 flox/flox mice (FS), sham-operated Acsl4 knockout mice (KS), TAC-operated Acsl4 flox/flox mice (FT), TAC-operated Acsl4 knockout mice (KT) n=3 mice/group. The heart tissue was isolated after 21 days after performing TAC or sham surgery.

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Project description:Balb/cJ mice on a low-fat diet show a decline in promoter H3K9-butyryl (H3K9Bu) in the heart, after subjecting them to transverse aortic constriction (TAC). In contrast, Balb/cByJ, which has a deletion in the ACADS gene, exhibit an increase in promoter H3K9Bu. Conversely, H3K9ac increases in the former and declines in the latter.

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Project description:Single-cell RNA sequencing of non-cardiomyocytes obtained from wild-type mouse hearts 20 days after transverse aortic constriction or sham surgery

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