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Genome-wide transcriptional changes induced by Cd2+ in Aspergillus nidulans

ABSTRACT: Genome-wide transcriptional changes induced by Cd2+ in Aspergillus nidulans

PROVIDER: PRJNA699311 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13623101.fastq.gz	Fastqsanger.gz
	SRR13623102.fastq.gz	Fastqsanger.gz
	SRR13623103.fastq.gz	Fastqsanger.gz
	SRR13623104.fastq.gz	Fastqsanger.gz
	SRR13623105.fastq.gz	Fastqsanger.gz

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Genome-wide transcriptional changes induced by Cd2+ in Aspergillus nidulans

Project description:Cd2+ pollution represents a serious global environmental risk. Understanding how microbes survive cadmium stress can facilitate the development of techniques to clean our environment and to prevent accumulation of this toxic heavy metal in the food chain. Genome-wide transcriptional changes induced by CdCl2 were determined and evaluated in Aspergillus nidulans. In addition to the reference strain, a atfA gene deletion mutant was also investigated to collect data on the regulatory role of AtfA transcription factor in this model organism. Up-regulation of the crpA Cu2+/Cd2+ pump and AN7729 putative bis(glutathionato)-cadmium transporter genes as well as transcriptional changes aiming to increase intracellular Cys availability were important parts of the efficient adaptation in both strains. Although deletion of atfA did not alter the cadmium tolerance of the fungus, the cadmium stress response of the mutant substantially differed from that of the reference strain. Promoter and transcriptional analyses of the “Two component signal transduction system” genes suggest that the AtfA-dependent regulation of these genes can be relevant in this phenomenon. We concluded that the regulatory network of A. nidulans has a high flexibility allowing the fungus to adapt efficiently to stress both in the presence and absence of this important transcription factor.

2021-07-28 | GSE166128 | GEO

Expression analysis of Aspergillus nidulans AN1599 (PbcR) overexpression mutant

2012-04-16 | GSE32954 | GEO

Expression analysis of Aspergillus nidulans OE::rsmA

Project description:Investigation of whole genome gene expression level changes in Aspergillus nidulans OE::rsmA compared to wild-type RDIT9.32 (veA). A twelve array study using total RNA recovered from six separate cultures of Aspergillus nidulans wild-type RDIT9.32 (veA) and six separate cultures of Aspergillus nidulans overexpressing rsmA (restorer of secondary metabolism A), using custom-designed, four-plex arrays. The experiment was divided into two runs. In the first run, three biological replicates each of Aspergillus nidulans wild-type RDIT9.32 (veA) and Aspergillus nidulans carrying a plasmid overexpressing rsmA under the control of the gpdA promoter were assayed. In the second run, three biological replicates each of Aspergillus nidulans wild-type RDIT9.32 (veA) and Aspergillus nidulans overexpressing rsmA at the native locus under the control of the gpdA promoter were assayed.

2012-01-17 | E-GEOD-34220 | biostudies-arrayexpress

Expression analysis of Aspergillus nidulans OE::rsmA

Project description:Investigation of whole genome gene expression level changes in Aspergillus nidulans OE::rsmA compared to wild-type RDIT9.32 (veA).

2012-01-17 | GSE34220 | GEO

Transcriptome changes initiated by carbon starvation in Aspergillus nidulans (Microbiology-SGM, 2013, Vol:159)

Project description:Transcriptional profiling of Aspergillus nidulans comparing control (growing on glucose) and carbon starving cultures.

2020-04-08 | GSE42610 | GEO

Expression analysis of Aspergillus nidulans AN1599 (PbcR) overexpression mutant

Project description:Investigation of whole genome gene expression level changes in Aspergillus nidulans AN1599 (PbcR) overexpression mutant, compared to the FGSC A4 wild-type strain. Overexpression of the Zn(II)2Cys6 M-bM-^@M-^Stype transcription factor, AN1599.4 (PbcR, pimaradiene biosynthetic cluster regulator), activates a secondary metabolite gene cluster in Aspergillus nidulans. Activation of the pathway in Aspergillus nidulans lead to a production of ent-pimara-8(14),15-diene. 12x135K array of two separate cultures of FGSC A4 and two separate cultures of oe:AN1599(PbcR) with three separate RNA extractions from each culture. Each 135K array measures expression level of 10,546 genes with 6 probes/transcript. In addition, the array format contains tiling probes for 36 longer transcripts. All probes are in duplicates, giving the total number of 137,562 probes per array.

2012-04-15 | E-GEOD-32954 | biostudies-arrayexpress

Gene expression in Aspergillus nidulans on multiple nitrogen sources

Project description:Stranded RNA-seq of wild type Aspergillus nidulans during growth on a range of nitrogn sources

2021-05-06 | GSE145035 | GEO

Interaction of Aspergillus nidulans and Streptomyces rapamycinicus

Project description:Gene expression analysis of four different treatments of Aspergillus nidulans. reference line (A.nidulans), line A (A.nidulans + Streptomyces rapamycinicus), line B (A.nidulans + orsellinic acid), line C (A.nidulans + lecanoric acid)

2011-05-25 | GSE25266 | GEO

Suberin degradation by Aspergillus nidulans

Project description:The study aims essentially at the characterisation of suberin degradation mechanisms by Aspergillus nidulans, at a fundamental level. Suberin is an important protective barrier in plant, thus the study of its biodegradation significantly impacts on phytopatology. In addition, fungal suberin degrading enzymes might provide important insights to develop new waste management, bioremediation and biodeterioration prevention strategies.

2014-07-31 | GSE54427 | GEO

Genome-wide transcriptional changes induced by different carbon sources and carbon starvation in Aspergillus nidulans

Project description:Understanding the coordinated regulation of the hundreds of carbohydrate-active enzyme (CAZyme) genes occurring in the genomes of fungi has great practical importance. We recorded genome-wide transcriptional changes of Aspergillus nidulans cultivated on glucose, lactose or arabinogalactan as well as under carbon starved conditions. We determined both carbon stress specific changes (a carbon stress vs. glucose) and culture specific changes (a culture vs. all other cultures). Many CAZyme genes showed carbon stress specific and/or culture specific upregulation on arabinogalactan (138 and 62 genes, respectively). Besides galactosidase and arabinan degrading enzyme genes, enrichment of cellulolytic, pectinolytic, mannan and xylan degrading enzyme genes were observed in these gene sets. Less, 81 and 107 carbon stress specific as well as 6 and 16 culture specific upregulated genes were found on lactose and in carbon starved cultures, respectively. They were enriched only in galactosidase and xylosidase genes on lactose and rhamnogalacturonanase genes in both cultures. Some CAZyme genes (29 genes) showed culture specific upregulation on glucose and they were enriched in beta-1,4-glucanase genes. Behavioral ecological background of these characteristics was evaluated to organize comprehensively our knowledge on CAZyme production, which can lead to develop new strategies to produce enzymes for plant cell wall saccharification.

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