Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The impact of exposure to excess zinc on the transcriptome of Streptococcus mutans

ABSTRACT: The impact of exposure to excess zinc on the transcriptome of Streptococcus mutans

PROVIDER: PRJNA702540 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13734500.fastq.gz	Fastqsanger.gz
	SRR13734501.fastq.gz	Fastqsanger.gz
	SRR13734502.fastq.gz	Fastqsanger.gz
	SRR13734503.fastq.gz	Fastqsanger.gz
	SRR13734504.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

The impact of exposure to excess zinc on the transcriptome of Streptococcus mutans

Project description:Zinc is a micronutrientient that serves as an important co-factor necessary for enzymatic function. In the host environment, access to metals can be highy restricted. As excess metals can be toxic to the bacterial cell, the host immune system can utilize zinc intoxication as a defense mechanism against bacterial infection. Here, we wanted to identify the transcriptomic response when S. mutans UA159 is exposed to an excess of zinc.

2021-02-18 | GSE166993 | GEO

The impact of the halogenated phenazine HP-29 on the transcriptome of Streptococcus mutans with or without zinc supplementation

Project description:We sought to identify transcriptomic changes that arise when S. mutans is cultivated in the presence of HP-29 with or without zinc supplementation. Mid-logarithmic broth cultures of Streptococcus mutans UA159 were exposed to 0.025uM HP-29 or to 0.025uM HP-29 and 0.5mM ZnSO4 for 30 minutes. We compared this transcriptomic data to that of control cultures that were grown in medium (BHI) without exposure to HP-29 or ZnSO4

2025-06-01 | GSE296169 | GEO

Specific redox and iron homeostasis responses in the root tip of Arabidopsis upon zinc excess

Project description:Zinc (Zn) excess negatively impacts primary root growth in Arabidopsis. The effects of Zn excess on root growth processes in the root tip are not well understood. Transcriptomics, ionomics and metabolomics were used to examine the specific impact of Zn excess on the root tip (RT) compared to the remaining root (RR). Zn excess exposure resulted in shortened root apical meristem and elongation zone, with differentiation initiating closer to the tip of root. Zn accumulated at a lower concentration in the RT than in RR.

| MSV000095842 | MassIVE

The impact of H2O2 exposure on the transcriptome of Streptococcus mutans wild type and perR mutant strains

Project description:H2O2 is an oxidative stress agent known to trigger an upregulation in expression of detoxification genes in Streptococcus mutans. Following discovery of a spontaneously-occurring perR mutation, we wanted to compare the transcriptomic responses of H2O2 exposure in S. mutans strains bearing an intact perR or a perR deletion.

2020-09-17 | GSE158080 | GEO

Proteomic analysis of Macleaya cordata leaf under excess zinc

Project description:The objectives of this study were to investigate response and tolerance of Macleaya cordata to excess zinc based on comparative analysis of proteome.

2022-11-21 | PXD038219 |

GNPS - Specific redox and iron homeostasis responses in the root tip of Arabidopsis upon zinc excess

| MSV000095842 | GNPS

Transcriptome analysis of streptococus mutans UA159 and SMU_1995c knock out strain

Project description:Zinc is an essential divalent trace metal for living cells. Intracellular zinc homeostasis is critical to the pathogenicity and virulence of bacteria, however the strategies of zinc homeostasis maintain in Streptococcus mutans, an important causative pathogen of dental caries, is unknown. In this study, we examined the function of an ABC transporter AdcCBA and its transcription factor AdcR in S. mutans. Using RNA-Seq analysis, LacZ-reporter studies and gel mobility shift assay, we showed that a MarR family transcription factor AdcR directly regulates the activity of promoters of adcRCB and adcA in response to the concentration of zinc in their environmental niches. Deletion of adcR increases the sensitivity of S. mutans to excessive zinc supply. Taken together, our finding suggests that Adc regulon, consists of a zinc uptake transporter AdcCBA and a zinc-responsive repressor AdcR, plays a prominent role in the maintenance of intracellular zinc homeostasis of S. mutans.

2021-07-01 | GSE165796 | GEO

RNA-seq of suspension-grown vs. adherent Neisseria gonorrhoeae under conditions of zinc sequestration or zinc excess

Project description:Deep sequencing of cDNA of Neisseria gonorrhoeae bacteria that were grown in suspension or adherent to acid-washed glass coverslips, in media where zinc was sequestered or available in excess.

2022-12-12 | GSE191020 | GEO

The Impact of Zinc on de novo Development of Antibiotic Resistance

Project description:Antimicrobial resistance (AMR) is a global health crisis that is predicted to worsen. While improper antibiotic usage is an established driver, less is known on the impacts of metal supplements. Here, we probe the impact of zinc (Zn) on AMR. In conflict settings where diarrhea disease cases are high, Zn, which is associated with weapons of war, is given as a supplement for diarrhea treatment prior to antibiotics such as ciprofloxacin. In this study, we find that E. coli’s exposure order to zinc impacts resistance development, with increasing pre-exposure leading to accelerated ciprofloxacin resistance, while combined exposure of zinc with ciprofloxacin delays ciprofloxacin resistance. We did not find evidence that zinc pre-exposure leads to genetic changes or changes in antibiotic tolerance, though the lag phase and doubling time of E. coli was increased, suggesting gene expression may be changed. While the zinc phenotype was no longer observed if ciprofloxacin exposure did not occur right after zinc pre-exposure, the resulting elevated MIC was more stable. These results are important as they highlight the need to reexamine the clinical role of zinc in treating diarrheal diseases and assess if changes in resistance development observed in vitro are also observed in vivo.

2023-06-13 | GSE234536 | GEO

Transcriptomic analysis of Zinc treatment in Acinetobacter baumannii

Project description:In A. baumannii, adequate zinc acquisition is required for the bacterium to express its full virulence potential. In excess, zinc can also induce significant cellular toxicity. The impact of zinc toxicity on biological systems has primarily been linked to its ability to bind non-zinc metalloproteins. The consequences of zinc intoxication include enhanced oxidative stress susceptibility and alteration of carbon source utilisation.

2019-11-01 | GSE131943 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data