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Transcriptomic analysis of GLUD1-knockdown 786-0 cells under amino acid deprivation

ABSTRACT: Transcriptomic analysis of GLUD1-knockdown 786-0 cells under amino acid deprivation

PROVIDER: PRJNA704839 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13783109_1.fastq.gz	Fastqsanger.gz
	SRR13783109_2.fastq.gz	Fastqsanger.gz
	SRR13783110_1.fastq.gz	Fastqsanger.gz
	SRR13783110_2.fastq.gz	Fastqsanger.gz
	SRR13783111_1.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of GLUD1-knockdown 786-0 cells under amino acid deprivation

Project description:shGLUD1 and shNT 786-0 cells were pretreated by amino acid starvation for 12 hours, then total mRNA were extracted for sequencing.

2021-02-26 | GSE167514 | GEO

786-0 renal cell carcinoma cell line Everolimus treatment

Project description:We present transcriptome profiling of 786-0 renal cell carcinoma cell lines both with and without Everolimus, an mTOR inhibitorhbn

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DA Methylation patterns in decitabine treated 786-0 cells

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786-O and 786-VHL in EMCV study

Project description:786-0 is a cell line derived from a clear cell renal carcinoma. Previous studies have shown that the 786-O cell line harbors an inactivating mutation in the von-Hippel Lindau (VHL) gene. Mutations in the VHL gene occur in the majority of sporadic clear cell renal cell. To determine how inactivation of the VHL affects cellular functions, we created a derivative of 786-0, which we call 786-VHL in which a functional allele of VHL has been introduced back into the 786-O cell line. The renal cell carcinoma cell line 786-0, which harbors a mutated allele of VHL, was compared to a cell line derived from 786-0, termed 786-VHL, that contains a functional allele of VHL. Genes whose expression characteristics were dependent on functional VHL were identified.

2010-06-23 | E-GEOD-22256 | biostudies-arrayexpress

RNA-seq of a VHL-/- human renal cancer cell line 786-0 transfected with 3 vectors

Project description:The human renal cancer cell line 786-0 was transfected with 3 vectors allowing the doxycycline-inducible expression of 1) the full length wild type sequence of VHL: 786-0 VHL WT, VHL+/+, 2) the R167Q mutant : 786-0 R167Q, VHL mutated, 3) the empty vector : 786-0 EV, VHL-/-. The aim of the study was to examine whether the VHL-R167Q mutation, which is associated with a high risk of developping clear cell renal carcinomas, could impact the plasticity of renal carcinoma cells.

2021-12-09 | E-MTAB-11168 | biostudies-arrayexpress

DA Methylation patterns in decitabine treated 786-0 cells

Project description:DA Methylation patterns in decitabine treated 786-0 cells

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Gene expression profiling of 786-O cells with ZHX2 and p65 knockdown

Project description:We are examining the regulatory pathway of ZHX2 and p65 in clear cell renal cell carcinoma cell line 786-O

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Transcriptome analysis of normal control and miR-412-3p overexpressing in 786-0 cells

Project description:To explore the signaling network involving circDVL1, miR-412-3p, and its targets in ccRCC, we used RNA sequencing (RNA-seq) to identify potential miR-412-3p target genes in miR-412-3p overexpressing and control cells. RNA-seq data identified 392 mRNAs that were downregulated in miR-412-3p overexpressing 786-O cells

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Transcriptome analysis of J774A.1 macrophages undergoing amino acid deprivation

Project description:Phagocytosis represents a mechanism used by macrophages to remove pathogens and cellular debris. Recent evidence suggested that amino acid or glucose deprivation may cause an increase in phagocytosis of heat-inactivated Escherichia coli and Staphylococcus aureus by macrophages, but not the uptake of platelets, apoptotic cells or beads. Increased phagocytosis of bacteria could be blocked by phagocytosis inhibitors and depended on p38 MAP kinase activity. To examine potentially important downstream pathways linked to EBSS-induced starvation and p38 MAP kinase activation, a full genome microarray representing over 41,000 mouse genes or transcripts was probed with cDNA isolated from J774A.1 macrophages that were treated with EBSS, EBSS supplemented with the p38 inhibitor SB202190 or control medium supplemented with 10% fetal bovine serum. Keywords: autophagy, heterophagy, p38 MAP kinase, scavenger receptor A, starvation Prior to RNA isolation, J774A.1 macrophages were incubated in RPMI 1640 medium supplemented with (i) 10% fetal bovine serum, (ii) Earleâs Balanced Salt Solution (EBSS) or (iii) EBSS supplemented with 10 ÂµM SB202190 for 6 hours.

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