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Antitumor effects of the hydralazine-valproate combination in lymphoma

ABSTRACT: Antitumor effects of the hydralazine-valproate combination in lymphoma

PROVIDER: PRJNA713994 | ENA |

REPOSITORIES: ENA

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Antitumor effects of the hydralazine-valproate combination in lymphoma

Project description:Epigenetic alterations are common in both B cell and T cell lymphomas. These contribute to lymphomagenesis and treatment resistance, hence epigenetic therapy is being investigated. We evaluated the effects of the DNA-methyltrasferase inhibitor hydralazine and the histone deacetylase inhibitor valproate in T-cell lymphoma HuT78 cells and B-cell lymphoma Raji cells.

2021-03-13 | GSE168790 | GEO

Combination Therapy with Nisin, Urolithin B, and Vincristine Exhibits Synergistic Antiproliferative and Pro-Apoptotic Effects Against Human Lymphoma Cells: Evidence From Proteomics

Project description:This study investigates the synergistic antitumor efficacy of a triple combination therapy—Nisin (N), Urolithin B (UB), and Vincristine (Vinc)—against human HBK11 lymphoma cells, with an emphasis on proteomic mechanisms of action. The findings elucidate the molecular underpinnings of this novel combination and underscore the potential of postbiotics as adjuvants to conventional chemotherapy, offering a mechanistically informed strategy for improved lymphoma treatment.

2025-09-19 | PXD065631 | Pride

Combination therapy with oncolytic virus and adoptively transferred T cells or mRNA vaccine amplifies antitumor effects [scRNA-Seq]

Project description:Adoptive T-cell therapy or oncolytic virotherapy has made significant progress, but the efficacy was limited by the lack of infiltration into solid tumors when used alone. Here, an oncolytic virus (rVSV-LCMVG) was designed and combined with adoptively transferred T cells. By turning cold tumors hot, in B16 tumor-bearing mice, combination therapy showed superior antitumor effects than monotherapy, whether rVSV-LCMVG was administered intratumorally or intravenously. Combination therapy significantly increased cytokine and chemokine levels within tumors and sensitized refractory tumors by boosting T-cell recruitment, down-regulating the expression of PD1, and restoring effector-T cell function. To offer a combination therapy with greater translational value, mRNA vaccines were introduced to induce tumor-specific T cells instead of adoptively transferred T cells, and exhibited comparable amplified anti-tumor effects. This study proposed a rational combination therapy of oncolytic virus with adoptive T-cell transfer or mRNA vaccines encoding tumor-associated antigens, in terms of synergistic efficacy and mechanism.

2024-03-15 | GSE235290 | GEO

Combination therapy with oncolytic virus and adoptively transferred T cells or mRNA vaccine amplifies antitumor effects [RNA-Seq]

2024-03-15 | GSE235289 | GEO

The combination of cantharidin and anti-angiogenic therapeutics presents synergistic antitumor effects against pancreatic cancer

Project description:The combination of cantharidin and anti-angiogenic therapeutics presents synergistic antitumor effects against pancreatic cancer

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Combination therapy with oncolytic virus and adoptively transferred T cells or mRNA vaccine amplifies antitumor effects

Project description:Combination therapy with oncolytic virus and adoptively transferred T cells or mRNA vaccine amplifies antitumor effects

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Antitumor effects of PRMT5 inhibition in sarcomas

Project description:Antitumor effects of PRMT5 inhibition in sarcomas

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Antitumor effects of DOT1L inhibition in retinoblastoma

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Dual Targeting of PI3Kδ and PPARα Enhances Antitumor Activity via FoxO1 Activation in Follicular Lymphoma

Project description:Follicular lymphoma (FL) frequently exhibits relapse and resistance to targeted therapy, underscoring the need for rational combinations. Here, we demonstrate that the phosphoinositide 3-kinase-δ (PI3Kδ) inhibitor linperlisib combined with the pan-peroxisome proliferator-activated receptor (PPAR) agonist chiglitazar delivers robust antitumor activity across FL models, including cell-derived and patient-derived xenografts, with a favorable tolerability profile. The combined regimen enforces G1/S arrest and apoptosis and exerts complementary metabolic–signaling effects by suppressing glycolysis, activating PPARα-driven programs, and relieving PI3K/AKT-mediated repression of forkhead box protein O1 (FoxO1). Genetic depletion of FoxO1 blunts treatment responses, indicating that FoxO1 activity is a pharmacodynamic biomarker and potential predictor of benefit. Compared with monotherapy, the combination consistently achieves superior tumor control in vivo without overt toxicity, indicating clinical translation potential. Collectively, these data support the clinical evaluation of linperlisib plus chiglitazar in FL, with prospective assessment of FoxO1 activity as a pharmacodynamic biomarker.

2026-04-08 | GSE311442 | GEO

Effect of Sodium Valproate on Rat Primary Hepatocytes.

Project description:This study provides an evaluation of changes in gene expression associated with sodium valproate treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (500 uM and 10 mM) of sodium valproate and water vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.

2012-08-28 | GSE40338 | GEO

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