Ontology highlight
ABSTRACT:
PROVIDER: PRJNA714759 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Corticotroph pituitary neuroendocrine tumors (PitNETs) are heterogeneous sellar neoplasms with variable clinical manifestations and outcomes. This deposit comprises proteomic data generated as part of an integrative meta-analysis of corticotroph PitNETs, which included epigenomic, transcriptomic, and proteomic investigations. Proteomic profiling was performed on 39 internal tumor samples. These data were integrated with previously published external molecular datasets. The combined analyses defined four clinically relevant molecular subgroups of corticotroph PitNETs.
2026-07-02 | PXD073952 | Pride
Project description:Corticotroph pituitary neuroendocrine tumors (PitNETs) are heterogeneous sellar neoplasms with variable clinical manifestations and growth behaviour. In this study, epigenomic data was generated as part of an integrative meta-analysis of corticotroph PitNETs, which included epigenomic, transcriptomic, and proteomic investigations. This deposit comprises idat files of tumor samples and adenohypophysial non-neoplastic control samples. These data were integrated with previously published external molecular datasets. The combined analyses defined four clinically relevant molecular subgroups of corticotroph PitNETs.
2026-07-03 | E-MTAB-16589 | biostudies-arrayexpress
Project description:Microarray analysis of an RXR agonist HX630 regulated gene expression in murine pituitary corticotroph tumor cells (AtT20 cell)
| PRJNA187420 | ENA
Project description:CGH array analysis was performed on 195 fresh-frozen pituitary tumors (56 gonadotroph, 11 null-cell, 56 somatotroph, 39 lactotroph and 33 corticotroph), with 5 years post-surgery follow-up
2021-01-01 | E-MTAB-9237 | biostudies-arrayexpress
Project description:Background: USP8 mutations are the most common driver changes in corticotroph pituitary tumors. They have direct effect on cells’ proteome through disturbance of ubiquitination process and also influence gene expression. The aim of this study was to compare microRNA profiles in USP8- mutated and wild-type tumors and determine the probable role of differential microRNA expression by integrative microRNA and mRNA analysis. Methods: Patients with Cushing’s disease (n = 28) and silent corticotroph tumors (n = 20) were included. USP8 mutations were identified with Sanger sequencing. MicroRNA and gene expression was determined with next-generation sequencing. Results: USP8-mutated patients with Cushing’s disease showed higher rate of clinical remission and trend towards lower tumor volume than wild-type patients. Comparison of microRNA profiles of USP8-mutated and wild-type tumors revealed 68 differentially expressed microRNAs. Their target genes were determined by in silico prediction and microRNA/mRNA correlation analysis. GeneSet Enrichment analysis of putative targets showed that the most significantly overrepresented genes are involved in protein ubiquitination-related processes. Only few microRNAs influence the expression of genes differentially expressed between USP8-mutated and wild-type tumors. Conclusions: Differences in microRNA expression in corticotropinomas stratified according to USP8 status reflect disturbed ubiquitination processes, but do not correspond to differences in gene expression between these tumors.
2021-02-06 | GSE166279 | GEO
Project description:The pituitary tumors (PA) arise in adenohypophyseal cells and are the second most common tumor in central nervous system. Reflective of their monoclonal cell of origin these tumors could be classified according to the hormone that they produce. The mutational and copy number variation burden in these tumors are scarce, indicating other molecular events are involved in pituitary tumorigenesis. Here we show throughout transcriptome and methylome analysis that there are three readily distinctive molecular signatures. The first group is comprised by the gonadotropes, null cell and silent corticotroph PA, the second group comprised by ACTH PA and the group cluster together the TSH-, PRL- and GH- PA. These groups showed CACNA2D4, EPHA4 and SLIT1 gene up-regulation, respectively. Pathway enrichment analysis support the previous observations. The calcium signaling pathway is characteristic for gonadotropes null cell and silent corticotroph, the Renin-Angiotensin system for the ACTH PA and the Fatty acid metabolisms for the TSH-, PRL-, GH- cluster. The analysis of scRNA-seq from non-tumoral pituitary tissue revealed that these three groups originate since the pituitary development/embryogenesis. The immune cell infiltration landscape revealed that PA could be potentially infiltrated by NK and mast cells. Taken together these results correlate with the expression of the NR5A1, TBX19 and POU1F1 transcription factors, which drive pituitary embryogenesis and theoretically tumorigenesis and potentially indicates three divergent cell precursors cells. We used microarrays to detail the molecular alteration in PA compared to non-tumoral gland.
2020-11-16 | GSE147786 | GEO
Project description:miRNA landscape of corticotroph pituitary neuroendocrine tumor from bilateral petrosal sinus sampling
| PRJNA688314 | ENA
Project description:Human monocyte derived macrophage microarray analysis
| PRJNA222315 | ENA