Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of Cop1 on chromatin accessibility in 4T1 mouse triple negative breast cancer cells

ABSTRACT: Role of Cop1 on chromatin accessibility in 4T1 mouse triple negative breast cancer cells

PROVIDER: PRJNA731516 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14607662_1.fastq.gz	Fastqsanger.gz
	SRR14607662_2.fastq.gz	Fastqsanger.gz
	SRR14607663_1.fastq.gz	Fastqsanger.gz
	SRR14607663_2.fastq.gz	Fastqsanger.gz
	SRR14607664_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Role of Cop1 on transcriptional output in 4T1 mouse triple negative breast cancer cells

Project description:Role of Cop1 on transcriptional output in 4T1 mouse triple negative breast cancer cells

| PRJNA719746 | ENA

Role of Cop1 on chromatin accessibility in 4T1 mouse triple negative breast cancer cells

Project description:Cop1 regulates stability of transcription factors. We determined the role of Cop1 in the regulation of Cebpd transciptional output. We generated 4T1breast cancer cells with CRISPR/Cas9 mediated Cop1 (gene symbol RFWD2) knockout. We treated control sgRosa26 and sgCop1 cells with vehicle or IFNgamma (20ng/ml) for 24 hours and did ATAC-seq.

2021-05-21 | GSE174784 | GEO

Role of Cop1 on transcriptional output in 4T1 mouse triple negative breast cancer cells

2021-04-30 | GSE171467 | GEO

Transcriptomic profiling of Cosmc-silenced Tn+ 4T1 cells-bearing triple-negative tumors in mice

Project description:Aberrant O-glycosylation and accumulation of the Tn antigen are associated with aggressive phenotypes in triple-negative breast cancer (TNBC). To investigate the transcriptomic consequences of Tn antigen expression, we analyzed gene expression profiles of murine 4T1 breast cancer cells carrying CRISPR/Cas9-mediated silencing of the Cosmc gene (Tn+) compared with parental wild-type 4T1 cells (WT). Total RNA was extracted from 4T1 cells-bearing tumors from mice (Tn and WT)s and subjected to RNA sequencing using Illumina NovaSeq X technology.

2026-06-10 | GSE332663 | GEO

Impact of PD-L1 overexpression on immune checkpoint inhibitor efficacy in triple-negative breast cancer using a 4T1 murine model.

Project description:Bulk RNA sequencing was performed to investigate transcriptomic changes in 4T1 tumors treated with anti-PD-L1 therapy. Tumors were derived from 4T1 control and PD-L1-overexpressing cells injected into mice, followed by IgG or anti-PD-L1 treatment. Gene expression analysis revealed distinct immune-related pathway alterations, with reduced immune activation in PD-L1-overexpressing tumors. Differentially expressed genes suggested an immunosuppressive tumor microenvironment, potentially contributing to resistance to anti-PD-L1 therapy. These findings provide insights into the molecular mechanisms underlying immune checkpoint inhibitor response in triple-negative breast cancer.

2025-03-28 | GSE292013 | GEO

Transcriptomic profiling of triple-negative breast cancer in a syngeneic mouse model undergoing fasting

Project description:Transcriptomic profiling of triple-negative breast cancers in a syngeneic mouse model (4T1 bearing BALB/c mice) undergoing cycles of fasting (48-hours of water-only fasting, every 7 days) vs. ad libitum diet (control group).

2025-08-07 | E-MTAB-14421 | biostudies-arrayexpress

Genome-wide maps of chromatin accessibility of histone deacetylase inhibition in triple-negative breast cancer

Project description:Analysis of chromatin accessibility changes after prolonged exposure of triple-negative breast cancer cell lines to low doses of Panobinostat (LBH589), a pan-histone deacetylase inhibitor.

2017-02-14 | GSE92898 | GEO

Transcriptomic profiling of Cosmc-silenced Tn+ 4T1 cells-bearing triple-negative tumors in mice

Project description:Transcriptomic profiling of Cosmc-silenced Tn+ 4T1 cells-bearing triple-negative tumors in mice

| PRJNA1468737 | ENA

Role of Cebpd on transcriptional output in 4T1 mouse triple negative breast cancer cells

Project description:Role of Cebpd on transcriptional output in 4T1 mouse triple negative breast cancer cells

| PRJNA725145 | ENA

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

Project description:Cop1 regulates stability of transcription factors. We found that Cop1 can regulate the proteasomal degradation of Cebpd. We generated 4T1 breast cancer cells with CRISPR/Cas9 mediated Cop1 (gene symbol RFWD2) knockout. We used Cebpd antibody to pulldown the DNA fragments binding with Cebpd and did ChIP-seq.

2021-05-23 | GSE175332 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data