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Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos

ABSTRACT: Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos

PROVIDER: PRJNA742034 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14932300_1.fastq.gz	Fastqsanger.gz
	SRR14932300_2.fastq.gz	Fastqsanger.gz
	SRR14932301_1.fastq.gz	Fastqsanger.gz
	SRR14932301_2.fastq.gz	Fastqsanger.gz
	SRR14932302_1.fastq.gz	Fastqsanger.gz

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Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos [ada2b]

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iChiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos [chiffon]

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Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos [ChIP-seq]

Project description:Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos [ChIP-seq]

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Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos.

Project description:The histone acetyltransferase Gcn5 is critical for gene expression and development. In Drosophila, Gcn5 is part of four complexes (SAGA, ATAC, CHAT and ADA) that are essential for fly viability and have key roles in regulating gene expression. Here, we show that although the SAGA, ADA and CHAT complexes play redundant roles in embryonic gene expression, the insect-specific CHAT complex uniquely regulates expression of a subset of developmental genes. We also identify a substantial decrease in histone acetylation in chiffon mutant embryos that exceeds that observed in Ada2b, suggesting broader roles for Chiffon in regulating histone acetylation outside of the Gcn5 complexes. The chiffon gene encodes two independent polypeptides that nucleate formation of either the CHAT or Dbf4-dependent kinase (DDK) complexes. DDK includes the cell cycle kinase Cdc7, which is necessary for maternally driven DNA replication in the embryo. We identify a temporal switch between the expression of these chiffon gene products during a short window during the early nuclear cycles in embryos that correlates with the onset of zygotic genome activation, suggesting a potential role for CHAT in this process. This article has an associated First Person interview with the first author of the paper.

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Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos

Project description:This SuperSeries is composed of the SubSeries listed below.

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iChiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos [chiffon]

Project description:Purpose: The goal of this study was to identify the differential expressed genes in the Drosophila embryo when chiffon is disrupted.

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Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos [ada2b]

Project description:Purpose: The goal of this study was to identify the differential expressed genes in the Drosophila embryo when ada2b is disrupted.

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Project description:Purpose: The goal of this study was to identify H3K14ac levels in chiffon mutant vs WT

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