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Regulation of influenza A virus infection by Lnc-PINK1-2:5

ABSTRACT: Regulation of influenza A virus infection by Lnc-PINK1-2:5

PROVIDER: PRJNA744902 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15074093_1.fastq.gz	Fastqsanger.gz
	SRR15074093_2.fastq.gz	Fastqsanger.gz
	SRR15074094_1.fastq.gz	Fastqsanger.gz
	SRR15074094_2.fastq.gz	Fastqsanger.gz
	SRR15074095_1.fastq.gz	Fastqsanger.gz

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Regulation of influenza A virus infection by Lnc-PINK1-2:5

Project description:A549 cells were transduced with a lentivirus expressing lnc-PINK1-2:5 at a MOI of 200 for 48 h. The cells were then infected with PR/8 at a MOI of 0.01 for 48 h. RNA-seq was done on the RNA samples from three vector control and three lnc-PINK1-2:5-overexpressing cells.

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Regulation of influenza A virus infection by Lnc-PINK1-2:5.

Project description:Influenza virus causes approximately 291,000 to 646,000 human deaths worldwide annually. It is also a disease of zoonotic importance, affecting animals such as pigs, horses, and birds. Even though vaccination is being used to prevent influenza virus infection, there are limited options available to treat the disease. Long noncoding RNAs (lncRNAs) are RNA molecules with more than 200 nucleotides that do not translate into proteins. They play important roles in the physiological and pathological processes. In this study, we identified a novel transcript, Lnc-PINK1-2:5 that was upregulated by influenza virus. This lncRNA was predominantly located in the nucleus and was not affected by type I interferons. Overexpression of Lnc-PINK1-2:5 reduced the influenza viral mRNA and protein levels in cells as well as titres in culture media. Knockdown of Lnc-PINK1-2:5 using CRISPR interference enhanced the virus replication. Antiviral activity of Lnc-PINK1-2:5 was independent of influenza virus strains. RNA sequencing analysis revealed that Lnc-PINK1-2:5 upregulated thioredoxin interacting protein (TXNIP) during influenza virus infection. Overexpression of TXNIP reduced influenza virus infection, suggesting that TXNIP is an antiviral gene. Knockdown of TXNIP abolished the Lnc-PINK1-2:5-mediated increase in influenza virus infection. In conclusion, the newly identified Lnc-PINK1-2:5 isoform is an anti-influenza lncRNA acting through the upregulation of TXNIP gene expression.

| S-EPMC8995437 | biostudies-literature

RNA-seq data of 293T cells trasfected with long non-coding RNA Lnc#61 or vehicle pcDNA3.1, and then infected or non-infected with the H5N1 avian influenza virus CK10 strain

Project description:Lnc#61 is a Long non-coding RNA that inhibits the replication of H5N1 subtype of influenza A virus However, the mechanism of role of Lnc#61 against highly pathogenic avian influenza virus (HPAIV) H5N1 subtype in mammalian cells is largely unknown. By functional analysis, we want to investigate host factors involved in Lnc#61's antiviral activity in infected or non-infected 293T cells

2025-05-16 | GSE213790 | GEO

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