Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency

ABSTRACT: A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency

PROVIDER: PRJNA745355 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15096400.fastq.gz	Fastqsanger.gz
	SRR15096401.fastq.gz	Fastqsanger.gz
	SRR15096402.fastq.gz	Fastqsanger.gz
	SRR15096403.fastq.gz	Fastqsanger.gz
	SRR15096382.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 22

Similar Datasets

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Latent reactivation]

Project description:A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Latent reactivation]

| PRJNA745356 | ENA

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [dRNA-seq]

Project description:A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [dRNA-seq]

| PRJNA745358 | ENA

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Lytic infection]

Project description:A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Lytic infection]

| PRJNA745357 | ENA

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Latent reactivation]

Project description:In a major study, we found that miR-aU14, a potential miRNA expressed by human herpesvirus 6A (HHV-6A), acts to selectively inhibit the processing of members of the human miR-30 family through direct RNA:RNA interaction and causes changes in mitochondrial arcchitecture through p53-Drp1 axis. In order to characterize miR-aU14 during virus reactivation, we carried out small RNA-seq from U2-OS cells carrying latent HHV-6A. Virus reactivation was carried out using 80 ng/ml of Trichostatin-A (TSA).

2022-02-15 | GSE179864 | GEO

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Lytic infection]

2022-02-17 | GSE179865 | GEO

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [dRNA-seq]

Project description:In a major study, we found that miR-aU14, a potential miRNA expressed by human herpesvirus 6A (HHV-6A), acts to selectively inhibit the processing of members of the human miR-30 family through direct RNA:RNA interaction and causes changes in mitochondrial arcchitecture through p53-Drp1 axis. In order to characterize miR-aU14, we carried out differentia lRNA-seq (dRNA-seq) from HHV-6A lytic infected HSB2 cells.

2022-02-17 | GSE179866 | GEO

Stress triggers expression of bovine herpesvirus 1 infected cell protein 4 (bICP4) RNA during early stages of reactivation from latency in pharyngeal tonsil

Project description:Bovine herpesvirus 1 (BoHV-1), an important pathogen of cattle, establishes lifelong latency in sensory neurons within trigeminal ganglia (TG) after acute infection. The BoHV-1 latency-reactivation cycle, like other -herpesvirinae subfamily members, is essential for viral persistence and transmission. Notably, cells within pharyngeal tonsil (PT) also support a quiescent or latent BoHV-1 infection. The synthetic corticosteroid dexamethasone, which mimics the effects of stress, consistently induces BoHV-1 reactivation from latency allowing early stages of viral reactivation to be examined in the natural host. Based on previous studies, we hypothesized that stress-induced cellular factors trigger expression of key viral transcriptional regulatory genes. To explore this hypothesis, RNA-sequencing studies compared viral gene expression in PT during early stages of dexamethasone-induced reactivation from latency. Strikingly, RNA encoding infected cell protein 4 (bICP4), which is translated into an essential viral transcriptional regulatory protein, was detected 30 minutes after dexamethasone treatment. Ninety minutes after dexamethasone treatment bICP4 and to a lesser extent bICP0 RNA were detected in PT. All lytic cycle viral transcripts were detected within three hours after dexamethasone treatment. Surprisingly, the latency related (LR) gene, the only viral gene abundantly expressed in latently infected TG neurons, was not detected in PT during latency. In TG neurons, bICP0 and the viral tegument protein VP16 are expressed before bICP4 during reactivation suggesting distinct viral regulatory genes mediate reactivation from latency in PT versus TG neurons. Finally, these studies confirm PT is a biologically relevant site for BoHV-1 latency, reactivation from latency, and virus transmission.

2022-11-01 | GSE216685 | GEO

Protemics of human cell during HHV-6A reactivation

Project description:HHV-6A is a human herpesvirus that integrates into human sub telomeric regions to acquire latency. This latent virus frequently reactivates causing numerous diseases. The project was aimed to understand changes in host cell prteomics upon virus reactivation, which might helpin understanding the pathophysiology of virus reactivation.

2020-04-07 | PXD016211 | Pride

Barrier-to-autointegration Factor 1 (BAF) Promotes Gammaherpesvirus Reactivation from Latency

Project description:Gammaherpesviruses, including Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), are DNA viruses that are globally associated with human cancers and establish lifelong latency in the human population. Detection of gammaherpesviral infection by the cGAS-STING innate immune DNA-sensing pathway is critical for suppressing viral reactivation from latency, a process that promotes viral pathogenesis and transmission. We report that Barrier-to-autointegration factor 1 (BAF)-mediated suppression of the cGAS-STING signaling pathway is necessary for reactivation of KSHV and EBV. We demonstrate a novel role for BAF in destabilizing cGAS expression and show that BAF expression in latently infected, reactivating, or uninfected cells leads to suppression of type I interferon-mediated antiviral responses and inhibition of viral replication. Furthermore, BAF overexpression resulted in decreased cGAS expression at the protein level. These results establish BAF as a key regulator of the lifecycle of gammaherpesviruses and a potential target for treating viral infections and malignancies.

2022-12-12 | GSE200781 | GEO

A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-15 | GSE179867 | GEO